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Severe Mononeuritis Multiplex in Eosinophilic Granulomatous Polyangiitis: A Case Report
Reem Al Saadi1, Sarah AlQassimi1, Mohamed Abuzakouk2
1Internal Medicine, Cleveland Clinic Abu Dhabi, Abu Dhabi, ARE.
Cureus
|May 1, 2024
Summary
Eosinophilic granulomatous polyangiitis (EGPA) can present as severe limb weakness and pain, mimicking Guillain Barre syndrome. Early diagnosis of mononeuritis multiplex in EGPA is crucial for timely biologic treatment and improved patient outcomes.
Area of Science:
- Neurology
- Rheumatology
- Immunology
Background:
- Eosinophilic granulomatous polyangiitis (EGPA) is a rare systemic vasculitis.
- Peripheral neuropathy, specifically mononeuritis multiplex, is an uncommon but significant manifestation of EGPA.
Observation:
- A 48-year-old male presented with a month of progressive weakness, paresthesia, and severe pain in all four limbs.
- Initial diagnosis was Guillain Barre syndrome due to severe extremity weakness.
Findings:
- The patient was ultimately diagnosed with eosinophilic granulomatous polyangiitis (EGPA).
- Mononeuritis multiplex was a key diagnostic feature, initially leading to misdiagnosis.
Implications:
- Mononeuritis multiplex in EGPA requires prompt recognition and treatment with biologics.
- Timely intervention can halt disease progression and improve quality of life, preventing permanent limb weakness and pain.
