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Mesenchymal Stem Cells

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...

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Updated: Jun 27, 2025

Mesenchymal Stem Cell Regulation of Macrophage Phagocytosis; Quantitation and Imaging

Mesenchymal Stem Cell Regulation of Macrophage Phagocytosis; Quantitation and Imaging

Published on: July 16, 2021

Interplay between mesenchymal stem cells and macrophages: Promoting bone tissue repair.

Fei-Fan Zhang^1,2, Yang Hao^1,3, Kuai-Xiang Zhang^1,3

¹Molecular Biology Lab, Henan Luoyang Orthopedic Hospital (Henan Provincial Orthopedic Hospital), Zhengzhou 450000, Henan Province, China.

World Journal of Stem Cells

|May 1, 2024

Summary

Mesenchymal stem cells (MSCs) and macrophages dynamically interact to promote bone repair. Understanding this cross-talk enhances MSCs therapy for bone defects and other diseases.

Keywords:

Bone tissue damage Inflammation Macrophages Mesenchymal stem cells Tissue regeneration

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Last Updated: Jun 27, 2025

Mesenchymal Stem Cell Regulation of Macrophage Phagocytosis; Quantitation and Imaging

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Published on: July 16, 2021

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Area of Science:

Orthopedic treatment
Regenerative medicine
Tissue engineering

Background:

Bone tissue repair is a complex orthopedic challenge.
Mesenchymal stem cells (MSCs) show promise in clinical trials for bone defects.
MSCs and macrophages have a significant, bidirectional relationship.

Purpose of the Study:

To explore the intricate relationship between MSCs and macrophages in bone repair.
To highlight the role of MSC-macrophage cross-talk in immune regulation and tissue regeneration.
To provide insights for enhancing MSCs-based therapies.

Main Methods:

Review of existing literature on MSCs and macrophage interactions in bone repair.
Analysis of the regulatory mechanisms between MSCs and macrophages.
Examination of the impact on immune microenvironment and cell differentiation.

Main Results:

MSCs modulate macrophage proliferation, infiltration, polarization, and osteoclast differentiation.
Macrophages activate MSCs and mediate their multilineage differentiation.
The cross-talk is crucial for immune system regulation and tissue regeneration.

Conclusions:

The interplay between MSCs and macrophages is vital for effective bone tissue repair.
Harnessing this relationship can improve MSCs therapy efficacy for bone defects.
This understanding can guide MSCs applications in other disease treatments.