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P-selectin and C-reactive protein in relation to home blood pressure and coronary calcification: a SCAPIS substudy
Peder Af Geijerstam1,2, Karin Rådholm1,2, Lena Jonasson3
1Department of Health, Medicine and Caring Sciences, Faculty of Medicine and Health Sciences, Linköping University, Linköping, Sweden.
Insights
Elevated soluble P-selectin (sP-selectin) and high-sensitivity C-reactive protein (hsCRP) are linked to sustained hypertension. This suggests a connection between hypertension, inflammation, and platelet activity.
Area of Science:
- Cardiovascular Medicine
- Biomarkers
- Hypertension Research
Background:
- Soluble P-selectin (sP-selectin) and high-sensitivity C-reactive protein (hsCRP) are known hypertension markers.
- Their association with out-of-office blood pressure and coronary artery calcification is not well-established.
Purpose of the Study:
- To investigate the relationship between sP-selectin, hsCRP, and home blood pressure (BP).
- To examine the association with coronary artery calcification score and carotid artery plaques.
Main Methods:
- Cross-sectional study of 4548 participants from the Swedish CArdioPulmonary bioImage Study (SCAPIS).
- Evaluated office and home BP, sP-selectin, and hsCRP levels.
- Generalized linear models used to assess inflammatory markers in relation to BP and vascular markers.
Main Results:
- Higher sP-selectin and hsCRP levels were significantly associated with sustained hypertension.
- Elevated hsCRP also correlated with masked hypertension and carotid artery plaques.
- Odds ratios indicated increased likelihood of hypertension with higher marker quartiles.
Conclusions:
- Increased sP-selectin and hsCRP are independently associated with sustained hypertension.
- Findings suggest a link between hypertension, platelet activity (sP-selectin), and inflammation (hsCRP).
Background:
Soluble P-selectin (sP-selectin) and high-sensitivity C-reactive protein (hsCRP) have previously been associated with hypertension, but the relation with out-of-office blood pressure (BP) and coronary artery calcification score is unknown. We aimed to examine the relationship between sP-selectin, hsCRP and home BP, as well as coronary artery calcification score and carotid artery plaques.
Methods:
In the Swedish CArdioPulmonary bioImage Study (SCAPIS), 5057 randomly selected participants were evaluated with office and home BP using the semi-automatic Omron M10-IT device. For this cross-sectional study, participants with sP-selectin <4 standard deviations above mean and hsCRP <5 mg/l, representing low-grade inflammation, were included. Using generalized linear models, these inflammatory markers were evaluated in relation to BP classifications, as well as coronary artery calcification score and carotid artery plaques.
Results:
Of participants, 4548 were included in the analyses. The median age was 57.2 (53.4-61.2) years, and 775 (17.0%) reported taking medication for hypertension. Participants in the highest quartile of sP-selectin [odds ratio (OR) 1.67, 95% confidence interval (CI) 1.40-1.98, P < 0.001] and hsCRP [OR 2.25, (95% CI 1.89-2.60), P < 0.001] were more likely to have sustained hypertension. Participants in the highest quartile of hsCRP were also more likely to have masked hypertension, OR (95% CI) 2.31 (1.72-3.10), P < 0.001 and carotid artery plaques, OR (95% CI) 1.21 (1.05-1.38), P = 0.007.
Conclusion:
Increased sP-selectin and hsCRP were independently associated with sustained hypertension. These findings indicate an association between hypertension and platelet activity, as expressed by sP-selectin.
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