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Related Concept Videos

Liver Physiology01:30

Liver Physiology

518
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of  70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
518
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

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Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
531

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Related Experiment Video

Updated: Jun 27, 2025

Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen
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Acute liver failure in pregnancy.

Vijay Alexander1, Santosh J Benjamin2, Kandasamy Subramani3

  • 1Department of Hepatology, Christian Medical College, Vellore 632 004, India.

Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology
|May 1, 2024
PubMed
Summary

Pregnancy-associated acute liver failure (ALF) requires prompt diagnosis and management. Early identification of causes like HELLP syndrome and urgent delivery are crucial for preventing maternal mortality.

Keywords:
Acute fatty liver, gestationalHELLP syndromeLiver failureMaternal deathsPre-eclampsiaPregnancy complications

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Area of Science:

  • Hepatology
  • Obstetrics
  • Critical Care Medicine

Background:

  • Liver function abnormalities occur in a minority of pregnancies.
  • Severe liver injury and acute liver failure (ALF) can arise from various causes during pregnancy.
  • Pregnancy-associated liver diseases present unique challenges in diagnosis and management.

Purpose of the Study:

  • To review the evaluation, assessment, and management of pregnant patients with ALF.
  • To highlight the importance of understanding specific etiologies of ALF in pregnancy.
  • To emphasize timely and etiology-specific interventions, including urgent delivery.

Main Methods:

  • Literature review focusing on pregnancy-associated liver diseases and ALF.
  • Discussion of diagnostic approaches and management strategies.
  • Emphasis on multidisciplinary care in specialized centers.

Main Results:

  • Specific diseases like acute fatty liver of pregnancy, HELLP syndrome, and pre-eclampsia can manifest as ALF.
  • Prompt and targeted evaluation is essential for effective management.
  • Urgent delivery is a key intervention for certain pregnancy-associated liver conditions.

Conclusions:

  • Comprehensive understanding of ALF etiologies in pregnancy is vital for urgent evaluation.
  • Timely, etiology-specific management, particularly urgent delivery, is critical for reducing maternal mortality.
  • Optimal management of ALF in pregnancy necessitates a multidisciplinary approach.