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Updated: Jun 27, 2025
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Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library
Published on: April 6, 2012
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Role of microRNA-363 during tumor progression and invasion
Arya Nasimi Shad1, Iman Akhlaghipour1, Hawraa Ibrahim Alshakarchi2
1Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Journal of Physiology and Biochemistry
|May 1, 2024
Summary
MicroRNA-363 (miR-363) acts as a tumor suppressor, inhibiting cancer progression and metastasis. Its dysregulation in various cancers suggests potential as a non-invasive diagnostic marker and therapeutic target.
Area of Science:
- Molecular Biology
- Oncology
- Biochemistry
Background:
- Cancer remains a leading cause of death globally, with late diagnosis hindering treatment efficacy.
- MicroRNAs (miRNAs) are crucial regulators of cellular processes and stable biomarkers in body fluids.
- Dysregulation of miR-363 has been observed across numerous cancer types.
Purpose of the Study:
- To investigate the role of miR-363 in tumor progression and metastasis.
- To evaluate miR-363 as a potential non-invasive diagnostic marker and therapeutic target in cancer.
Main Methods:
- Literature review and analysis of existing studies on miR-363 function in cancer.
- Examination of miR-363's regulatory impact on key cellular processes and signaling pathways.
Main Results:
- miR-363 primarily exhibits tumor suppressor activity by regulating transcription factors, apoptosis, cell cycle, and structural proteins.
- miR-363 influences tumor progression through modulation of WNT, MAPK, TGF-β, NOTCH, and PI3K/AKT signaling pathways.
Conclusions:
- miR-363 plays a significant role in suppressing tumor development and metastasis.
- miR-363 holds promise as a novel non-invasive diagnostic biomarker and a potential therapeutic target for various cancers.
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