Related Experiment Video
Updated: Jun 27, 2025
Employing the Forced Oscillation Technique for the Assessment of Respiratory Mechanics in Adults
Published on: February 9, 2022
Dynamic indicators of acute respiratory diseases treatment in children after correction
Olesya M Horlenko1, Iryna Yu Pikina1, Lyubomyra B Prylypko1
1UZHHOROD NATIONAL UNIVERSITY, UZHHOROD, UKRAINE.
Insights
Optimized treatment significantly reduced inflammatory markers like C-reactive protein (CRP) and interferon-gamma (γ-IFN) in children with upper respiratory tract infections. These findings highlight improved metabolic adaptation and reduced oxidative stress following the intervention.
Area of Science:
- Pediatrics
- Immunology
- Respiratory Medicine
Background:
- Upper respiratory tract infections (URTIs) are common in school-aged children.
- Inflammation, oxidative stress, and metabolic adaptation are key factors in URTI pathology.
- Understanding these markers can inform treatment strategies.
Purpose of the Study:
- To investigate upper respiratory tract pathology in children.
- To analyze markers of inflammatory response, oxidative stress, and metabolic adaptation.
- To evaluate the effectiveness of an optimized treatment approach.
Main Methods:
- Study included 111 school-aged children (10-14 years) diagnosed with acute respiratory infections (viral/bacterial).
- Diseases included acute pharyngitis, acute bronchitis, and acute tonsillitis.
- Children were divided into optimized (n=60) and basic (n=51) treatment groups.
Main Results:
- Erythrocyte pool levels correlated with Interleukin-1 (IL-1), IL-4, and Tumor Necrosis Factor-alpha (TNF-α).
- Creatinine values showed correlations with IL-10, gamma-Interferon (γ-IFN), and TNF-α.
- Ferritin levels positively correlated with total protein and TNF-α.
Conclusions:
- Optimized treatment led to significant reductions in C-reactive protein (CRP) and γ-IFN levels.
- Correlation between urea levels and IL-2, IL-4 was observed.
- The study suggests optimized treatment improves inflammatory and metabolic markers in pediatric URTIs.
Objective:
Aim: To study the Respiratory pathology of the upper respiratory tract, markers of the inflammatory response of the organism, Oxidative stress, Metabolic adaptation and possibilities of correction.
Patients And Methods:
Materials and Methods: The study group (n=111) included school-aged children (10-14 years old). The general group of inflammatory diseases of the respiratory tract (J000-J06) was considered, with a diagnosis of acute respiratory infection (ARI) of viral and bacterial origin and included local inflammationof the upper respiratory tract with presentation of acute pharyngitis (68.0%), acute bronchitis (22,0%), acute tonsillitis (10,0%).
Results:
Results: Dynamic observation of groups of children who received optimized (group 1, n=60) and basic (group 2, n=51) treatment was carried out. The level of the erythrocyte pool correlated with IL-1 (r=-0,29, p=0,03), IL-4 (r=0,32, p=0,01), TNF-α (r=-0,35 , p=0,006). Creatinine value correlated with IL-10 (r=0,3, p=0,005), γ-IFN (r=0,42, p=0,001), TNF-α (r=0,25, p=0,05). Correlations of ferritin presented positive correlation values with the level of total protein (r=0,26, p=0,04) and TNF-α (r=0,41, p=0,001).
Conclusion:
Conclusions: After the optimized treatment, there was a significant decrease in the reliable levels of CRP and γ-IFN by 7 and 4,4 times (by groups) and 5,8 and 3,2 times (by groups), respectively. Correlation relationships of urea levels with IL-2,4 were detected. The level of the erythrocyte pool correlated with IL-1,4, TNF-α, Ferritin presented positive correlation values with the level of total protein,TNF-α .
Related Concept Videos
01:29Acute Respiratory Failure-V
Ensure that patients are monitored continuously for their response to therapy, including changes in...
01:23Acute Respiratory Failure-IV
01:19Respiratory Assessment: Purpose and Indications
Objectives and Importance:
The primary goal of respiratory assessment is to evaluate patients at early risk of clinical deterioration. Since respiratory distress often precedes other signs of declining health, breathing patterns and sounds become a...
01:23Assessment of Respiration
Subjective Assessment: Nurses interview the patient to gather information directly during the subjective assessment. It includes questions about the individual's medical history, medications, and symptoms, focusing on past respiratory conditions like...
01:17Pulmonary Cycle: Exhalation
01:20Assessment of Ventilation I: Respiratory Rate
A Ventilation assessment is critical for monitoring a patient's health status. Respiration, one of the most accessible vital signs, provides insights into the function of numerous body systems and can indicate serious health issues, such as brainstem injuries from head trauma.
Critical Guidelines for Assessing Ventilation: