Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Radical Chain-Growth Polymerization: Overview01:10

Radical Chain-Growth Polymerization: Overview

2.4K
Chain-growth or addition polymerization is successive addition reactions of monomers with a polymer chain. In radical chain-growth polymerization, the reaction proceeds via a free-radical intermediate. The free radical is formed from radical initiators, which spontaneously generate free radicals by homolytic fission. Organic peroxides (such as dibenzoyl peroxide, as shown in Figure 1) or azo compounds are popular radical initiators. A low concentration ratio of radical initiator to monomer is...
2.4K
Radical Chain-Growth Polymerization: Mechanism01:09

Radical Chain-Growth Polymerization: Mechanism

2.5K
The radical chain-growth polymerization mechanism consists of three steps: initiation, propagation, and termination of polymerization. The polymerization initiates when a free radical generated from the radical initiator adds to the unsaturated bond in the monomer. The unpaired electron of the free radical and one π electron in the unsaturated bond creates a σ bond between the free radical and the monomer. As a result, the other π electron in the unsaturated bond converts this...
2.5K
Radical Reactivity: Overview01:11

Radical Reactivity: Overview

2.1K
Radicals, the highly reactive species, gain stability by undergoing three different reactions. The first reaction involves a radical-radical coupling, in which a radical combines with another radical, forming a spin‐paired molecule. The second reaction is between a radical and a spin‐paired molecule, generating a new radical and a new spin‐paired molecule. The third reaction is radical decomposition in a unimolecular reaction, forming a new radical and a spin‐paired...
2.1K
Radical Reactivity: Nucleophilic Radicals01:16

Radical Reactivity: Nucleophilic Radicals

2.1K
Radicals adjacent to electron-donating groups are called nucleophilic radicals. These radicals readily react with electrophilic alkenes. The SOMO–LUMO interactions are the driving force for the reaction, where the high-energy SOMO of the electron-rich, nucleophilic radicals interacts with the low-energy LUMO of the electron-deficient, electrophilic alkenes. Such SOMO–LUMO interactions are the basis of reactive radical traps, affecting the selectivity in radical reactions. For...
2.1K
Free-Radical Chain Reaction and Polymerization of Alkenes02:35

Free-Radical Chain Reaction and Polymerization of Alkenes

7.8K
The conversion of alkenes to macromolecules called polymers is a reaction of high commercial importance. The structure of the polymer is defined by a repeating unit, while the terminal groups are considered insignificant. The average degree of polymerization represents the number of repeating units in the polymer molecule and is denoted by the subscript n.
7.8K
Radical Reactivity: Intramolecular vs Intermolecular01:33

Radical Reactivity: Intramolecular vs Intermolecular

1.7K
Radical reactions can occur either intermolecularly or intramolecularly. In an intermolecular radical reaction, a nucleophilic radical adds to an electrophilic alkene or vice versa. In such reactions, the radical and generally the alkene, which is also called the radical trap, are two different molecules. Additionally, for such intermolecular reactions to occur, the radical trap must be active, present in an excess concentration, and the radical starting material must have a weak...
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Polymer-Grafted Nanoparticles as All-in-One Nanoplatforms.

ACS polymers Au·2026
Same author

Oxygen-Tolerant Photo-Induced Miniaturized Accelerated Atom Transfer Radical Polymerization (OPTIMA-ATRP) for High-Throughput Synthesis of Polymer Bioconjugates.

Angewandte Chemie (International ed. in English)·2026
Same author

Enhanced B-N coordinated dynamic boronate chemistry for recyclable thermosets with elevated stability.

Nature communications·2026
Same author

Processing-Driven Control of the Properties of Polymer Grafted Nanoparticle Composites.

ACS nano·2026
Same author

Neutron Reflectometry Reveals Diffusion in Contrast-Matched Brush Particle Bilayers.

ACS macro letters·2026
Same author

Controlled Synthesis of Liquid-Crystalline Polymers Under Ambient Conditions by Red-Light-Driven ATRP.

Macromolecules·2026

Related Experiment Video

Updated: Jun 27, 2025

Atom Transfer Radical Polymerization of Functionalized Vinyl Monomers Using Perylene as a Visible Light Photocatalyst
06:49

Atom Transfer Radical Polymerization of Functionalized Vinyl Monomers Using Perylene as a Visible Light Photocatalyst

Published on: April 22, 2016

11.8K

Nucleic Acid-Binding Dyes as Versatile Photocatalysts for Atom-Transfer Radical Polymerization.

Jaepil Jeong1,2, Xiaolei Hu1, Rongguan Yin1

  • 1Department of Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, United States.

Journal of the American Chemical Society
|May 1, 2024
PubMed
Summary

Nucleic acid-binding dyes (NuABDs) can act as photocatalysts with nucleic acid scaffolds for controlled polymerization. This novel platform enables advanced applications in materials science and biotechnology.

More Related Videos

[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
09:12

[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst

Published on: May 21, 2019

9.2K
Free Radicals in Chemical Biology: from Chemical Behavior to Biomarker Development
14:22

Free Radicals in Chemical Biology: from Chemical Behavior to Biomarker Development

Published on: April 15, 2013

20.3K

Related Experiment Videos

Last Updated: Jun 27, 2025

Atom Transfer Radical Polymerization of Functionalized Vinyl Monomers Using Perylene as a Visible Light Photocatalyst
06:49

Atom Transfer Radical Polymerization of Functionalized Vinyl Monomers Using Perylene as a Visible Light Photocatalyst

Published on: April 22, 2016

11.8K
[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
09:12

[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst

Published on: May 21, 2019

9.2K
Free Radicals in Chemical Biology: from Chemical Behavior to Biomarker Development
14:22

Free Radicals in Chemical Biology: from Chemical Behavior to Biomarker Development

Published on: April 15, 2013

20.3K

Area of Science:

  • Biotechnology
  • Materials Science
  • Polymer Chemistry

Background:

  • Nucleic acid-binding dyes (NuABDs) are fluorogenic probes used in nanotechnology and biotechnology.
  • Their fluorescence upon binding nucleic acids enables various diagnostic and analytical applications.

Purpose of the Study:

  • To explore the potential of NuABDs as photocatalysts for atom-transfer radical polymerization (ATRP).
  • To investigate the thermodynamic and electrochemical properties influencing the photopolymerization mechanism.
  • To demonstrate the versatility of NuABD-based platforms with different nucleic acid scaffolds.

Main Methods:

  • Utilized NuABDs in conjunction with nucleic acid scaffolds (e.g., G-quadruplex DNA, DNA nanoflowers).
  • Investigated thermodynamic and electrochemical properties of the dyes.
  • Performed controlled atom-transfer radical polymerization (ATRP).

Main Results:

  • Demonstrated NuABDs as effective photocatalysts for precisely controlled ATRP when paired with nucleic acid scaffolds.
  • Gained insights into the mechanism driving photopolymerization through property investigations.
  • Successfully executed polymerizations using various NuABDs and nucleic acid structures.

Conclusions:

  • NuABD-based platforms offer a novel approach to controlled photopolymerization.
  • This extends applications in nucleic acid-based materials, biohybrids, and stimuli-responsive ATRP.