Trial of Electronic Medical Record Integrated Next-Generation Sequencing Ordering in Veterans Affairs Cancer Care
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View abstract on PubMed
Summary
This summary is machine-generated.Integrating next-generation sequencing (NGS) ordering into the electronic medical record (EMR) significantly increased NGS testing rates and speed for veterans with cancer. This improvement enhances oncology care within the Veterans Affairs (VA) health system.
Area Of Science
- Oncology
- Genomics
- Health Informatics
Background
- Next-generation sequencing (NGS) is underutilized in oncology care.
- Effective integration of NGS ordering into electronic medical records (EMRs) is crucial for improving patient outcomes.
Purpose Of The Study
- To evaluate the impact of integrating NGS ordering into the Veterans Affairs (VA) EMR system on oncology care.
- To assess changes in NGS testing rates and turnaround times for veterans with non-small cell lung and prostate cancer.
Main Methods
- A comparative study was conducted at two VA Medical Centers, comparing patients before (external ordering, EO) and after (internal ordering, IO) EMR integration of NGS ordering in July 2021.
- Patients with non-small cell lung cancer and prostate cancer were identified.
- Primary outcome: proportion of NGS testing performed; secondary outcomes: time from diagnosis to test receipt and result, and testing by race.
Main Results
- NGS testing increased significantly from 52% in the EO group to 87% in the IO group (P ≤ .01).
- Time from metastatic diagnosis to sample receipt by the vendor improved from median 299 days to 37 days (P = .03).
- Time from diagnosis to test result improved from median 309 days to 56 days (P = .03), with no significant difference in tissue receipt or testing by race.
Conclusions
- EMR integration of NGS ordering substantially increased the proportion and speed of testing for veterans with cancer.
- This initiative demonstrates a successful strategy for enhancing genomic testing in a large, vulnerable patient population within the VA system.
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