Genetic prediction of micronutrient levels and the risk of colorectal polyps: A mendelian randomization study
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View abstract on PubMed
Summary
This summary is machine-generated.Higher levels of selenium and beta-carotene may reduce the risk of colorectal polyps (CP). This Mendelian randomization study investigated 13 micronutrients, finding these two showed a protective effect against CP development.
Area Of Science
- Nutritional Epidemiology
- Genetic Epidemiology
- Gastroenterology
Background
- Conflicting evidence exists on the relationship between micronutrient levels and colorectal polyp (CP) risk.
- Previous studies have not definitively established the role of specific micronutrients in CP development.
Purpose Of The Study
- To investigate the causal relationship between 13 human micronutrients and genetic susceptibility to colorectal polyps (CP) using a two-sample Mendelian randomization (MR) approach.
- To clarify the influence of micronutrient status on the risk of developing CP.
Main Methods
- A two-sample Mendelian randomization (MR) study was conducted using summary statistics for CP (n=463,010) from pan-European genome-wide association studies (GWAS).
- Instrumental variables for 13 micronutrients were identified from published GWAS.
- Sensitivity analyses were performed to assess heterogeneity and pleiotropy, with inverse variance weighted methods used for primary estimation.
Main Results
- A genetic predisposition to elevated selenium (toenail and circulating) and serum beta-carotene concentrations was associated with a reduced risk of CP.
- No statistically significant associations were found between the remaining 11 investigated micronutrients and CP risk.
Conclusions
- Micronutrients selenium and beta-carotene may play a protective role in the development of colorectal polyps.
- These findings contribute to understanding the genetic and nutritional factors influencing CP risk.
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