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Related Experiment Video

Updated: Jun 27, 2025

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
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DHEA-S, Androstenedione, 17-β-estradiol signature as novel biomarkers for early prediction of risk of malignant

Barbara Nuvoli1, Andrea Sacconi2, Grazia Bottillo3

  • 1Preclinical Models and New Therapeutic Agents Unit, IRCCS Regina Elena National Cancer Institute, Rome 00144, Italy.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|May 1, 2024
PubMed
Summary

This study identifies 17-β-estradiol, DHEA-S, and androstenedione as potential biomarkers for early mesothelioma diagnosis in asbestos-exposed individuals. These steroid hormones can aid in timely intervention and improved patient care.

Keywords:
17-β-estradiolAndrostenedioneAsbestosDHEA-SMalignant pleural mesotheliomaUHPLC-MS/MS, Biomarker

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Area of Science:

  • Endocrinology
  • Oncology
  • Biomarker Discovery

Background:

  • Mesothelioma pathogenesis is linked to 17-β-estradiol.
  • Early diagnosis of mesothelioma remains a clinical challenge.
  • Steroid hormone precursors may serve as diagnostic indicators.

Purpose of the Study:

  • To investigate 17-β-estradiol and its precursors as potential biomarkers for mesothelioma.
  • To analyze steroid hormone profiles in mesothelioma patients and asbestos-exposed individuals.
  • To correlate gene expression with patient prognosis.

Main Methods:

  • Enzyme-linked immunosorbent assay (ELISA) for 17-β-estradiol.
  • Ultra-high performance liquid chromatography/tandem mass spectrometry (UHPLC-MS/MS) for 19 steroid hormone precursors.
  • Bioinformatics analysis and Cancer Genome Atlas data for gene expression analysis.

Main Results:

  • Significant differences in 17-β-estradiol levels were found between mesothelioma patients and healthy controls.
  • A DHEA-S-androstenedione-17-β-estradiol signature score effectively distinguished between asbestos-exposed and non-exposed groups.
  • Elevated 5-α-reductase1 and hydroxysteroid-17β-dehydrogenase2 gene expression correlated with worse and better overall survival, respectively.

Conclusions:

  • 17-β-estradiol, DHEA-S, and androstenedione show promise as biomarkers for mesothelioma risk and early diagnosis.
  • These biomarkers are particularly relevant for asbestos-exposed individuals, enabling timely intervention.
  • Steroid hormone profiles and specific gene expressions offer insights into mesothelioma prognosis.