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Kidney Transplant I: Introduction

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...

Kidney Transplant II: Surgical Procedure

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...

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Updated: May 9, 2026

Mouse Kidney Transplantation: Models of Allograft Rejection

Mouse Kidney Transplantation: Models of Allograft Rejection

Published on: October 11, 2014

Exploring kidney allograft rejection: A proof-of-concept study using spatial transcriptomics.

Cristina Martin-Martin¹, Beatriz Suarez-Alvarez¹, Monika González²

¹Translational Immunology, Health Research Institute of the Principality of Asturias (ISPA), Avenida de Roma S/N, 33011, Oviedo, Asturias, Spain; RICORS2040, Kidney Disease Research Network, ISCIII, Madrid, Spain.

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons

|May 1, 2024

Summary

This summary is machine-generated.

Spatial transcriptomics reveals distinct immune cell patterns in kidney allograft rejection. Gene expression signatures associated with rejection are concentrated in the renal interstitium, offering new insights into transplant pathology.

Keywords:

kidney transplantation protocol biopsy spatial transcriptomics

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Last Updated: May 9, 2026

Mouse Kidney Transplantation: Models of Allograft Rejection

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Published on: October 11, 2014

Application of Laser Microdissection to Uncover Regional Transcriptomics in Human Kidney Tissue

Application of Laser Microdissection to Uncover Regional Transcriptomics in Human Kidney Tissue

Published on: June 9, 2020

A Rat Orthotopic Renal Transplantation Model for Renal Allograft Rejection

A Rat Orthotopic Renal Transplantation Model for Renal Allograft Rejection

Published on: February 2, 2022

Area of Science:

Nephrology
Immunology
Genomics

Background:

Kidney allograft rejection poses a significant challenge in transplantation.
Understanding the spatial distribution of immune cells and gene expression is crucial for diagnosing and treating rejection.

Purpose of the Study:

To evaluate the utility of spatial transcriptomics in characterizing kidney allograft rejection.
To map gene expression patterns and immune cell signatures within different pathological states of renal allografts.

Main Methods:

Integration of spatial transcriptomics with public single-cell RNA sequencing data.
Analysis of kidney biopsy samples across nonrejection and rejection states (T cell-mediated acute rejection, interstitial fibrosis, tubular atrophy).
Mapping of immune cell types, chemokine receptors/ligands, and transcriptional signatures.

Main Results:

Identification of distinct spatial immune cell signatures (T/B lymphocytes, monocytes, mast cells, plasma cells) in the renal interstitium.
Demonstration of differential spatial enrichment of rejection-associated transcriptional signatures.
Higher enrichment scores for rejection signatures in interstitial regions compared to tubular areas.

Conclusions:

Spatial transcriptomics is valuable for uncovering cellular heterogeneity and immune signatures in renal transplant biopsies.
The study highlights the interstitial region as a key site for rejection-driven molecular and cellular processes.
This technology holds potential for advancing the study of transplant rejection mechanisms.