Incidence and Management of Radiation Cystitis After Pelvic Radiotherapy for Prostate Cancer: Analysis From a...

Area of Science:

• Oncology
• Urology
• Radiotherapy

Background:

• Pelvic radiotherapy (RT) for prostate cancer (PCa) can lead to radiation cystitis.
• Understanding the incidence, risk factors, and management of this complication is crucial for patient care.

Purpose of the Study:

• To determine the incidence of radiation cystitis in PCa patients undergoing pelvic RT.
• To evaluate common management strategies for radiation cystitis.
• To identify risk factors associated with its development.

Main Methods:

• Retrospective analysis of 274,865 PCa patients from 2011-2022 using the PearlDiver Mariner database.
• Identification of patients with radiation cystitis using ICD and CPT codes.
• Multivariate logistic regression to identify risk factors and analyze treatment trends.

Main Results:

• The incidence of radiation cystitis was 2.8% (7721 patients).
• Obesity (OR 1.29), smoking (OR 1.27), and diabetes (OR 1.32) were significant risk factors.
• Hyperbaric oxygen therapy showed a significant upward trend in use (16.67%).

Conclusions:

• Radiation cystitis is a rare but impactful complication of pelvic RT for PCa.
• Identified risk factors align with the condition's pathophysiology.
• Hyperbaric oxygen therapy is an emerging treatment modality.