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Related Experiment Video

Updated: Jun 27, 2025

Bioluminescent Bacterial Imaging In Vivo

Bioluminescent Bacterial Imaging In Vivo

Published on: November 4, 2012

Engineered bacterial therapeutics for detecting and treating CRC.

Nicole Siguenza¹, Arianna Brevi², Joanna T Zhang³

¹Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, CA, USA; Division of Gastroenterology and Hepatology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.

Trends in Cancer

|May 1, 2024

Summary

This summary is machine-generated.

Engineered bacteria show promise for early colorectal cancer (CRC) detection and treatment. These novel biological tools offer sensitive and specific methods for monitoring and potentially preventing cancer progression in high-risk individuals.

Keywords:

detection engraftment live bacterial therapeutics treatment

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Last Updated: Jun 27, 2025

Bioluminescent Bacterial Imaging In Vivo

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Colorectal Cancer Cell Surface Protein Profiling Using an Antibody Microarray and Fluorescence Multiplexing

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Measuring Growth and Gene Expression Dynamics of Tumor-Targeted S. Typhimurium Bacteria

Measuring Growth and Gene Expression Dynamics of Tumor-Targeted S. Typhimurium Bacteria

Published on: July 6, 2013

Area of Science:

Biotechnology
Oncology
Microbiology

Background:

Colorectal cancer (CRC) remains a leading cause of cancer mortality in the USA.
Early detection of CRC is challenging, particularly in high-risk populations.
Engineered bacteria are being explored for novel CRC detection and therapeutic strategies.

Purpose of the Study:

To investigate the potential of engineered bacteria for early CRC detection.
To evaluate engineered bacteria for monitoring the tumor microenvironment and preventing cancer progression.
To assess the feasibility of genetic circuits and biocontainment for therapeutic applications.

Main Methods:

Development and testing of novel genetic circuits in engineered bacteria.
In vitro and in vivo verification of bacterial functions for cancer applications.
Implementation of biocontainment measures for therapeutic readiness.

Main Results:

Engineered bacteria demonstrated potential for sensitive and specific detection of CRC.
Novel genetic circuits showed promise for therapeutic functions and enhancing existing treatments.
Biocontainment strategies were developed to meet therapeutic standards.

Conclusions:

Engineered bacteria represent a promising platform for sensitive and specific CRC detection.
These biological tools offer potential for monitoring cancer progression and enhancing treatment modalities.
Further development with biocontainment is crucial for clinical translation in CRC management.