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Nucleic acids based integrated macromolecular complexes for SiRNA delivery: Recent advancements
Dilpreet Singh1,2, Lovedeep Singh1, Simranjeet Kaur3
1University Institute of Pharma Sciences, Chandigarh University, Mohali, India.
Nucleosides, Nucleotides & Nucleic Acids
|May 2, 2024
Summary
Small interfering RNA (siRNA) therapies face delivery challenges. Recent innovations in macromolecular complexes enhance siRNA delivery for precise gene silencing and personalized medicine.
Area of Science:
- Biotechnology
- Molecular Biology
- Nanomedicine
Background:
- Small interfering RNA (siRNA) offers precise gene silencing for therapeutic applications.
- Significant challenges exist in vivo delivery, including nuclease degradation, poor cellular uptake, and immunogenicity.
Purpose of the Study:
- To review recent advancements in nucleic acid-based macromolecular complexes for efficient siRNA delivery.
- To evaluate innovative delivery vectors and strategies for overcoming biological barriers.
Main Methods:
- Analysis of lipid-based nanoparticles, polymeric carriers, dendrimer complexes, and hybrid systems.
- Evaluation of bioconjugation techniques, active targeting, and nanotechnology platforms.
- Assessment of stimuli-responsive elements for controlled siRNA release.
Main Results:
- Novel delivery systems demonstrate enhanced siRNA stability and cellular uptake.
- Targeted delivery strategies improve therapeutic efficacy and reduce off-target effects.
- Nanotechnology platforms show promise in overcoming biological barriers.
Conclusions:
- Integrated macromolecular complexes represent a significant advancement in siRNA delivery.
- Continued innovation in delivery systems is crucial for translating siRNA therapies to clinical practice.
- Emerging technologies hold potential for personalized medicine applications.
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