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Pulmonary mucinous adenocarcinoma: An overview of pathophysiology and advancements in treatment

Lihui Ge1, Linlin Wang2, Dongmei Pei1

  • 1Department of Health Management, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.

Heliyon
|May 2, 2024
PubMed

Insights

Pulmonary mucinous adenocarcinoma (PMA), a rare non-small cell lung cancer (NSCLC) subtype, has unique features. This review covers PMA diagnosis, treatment, and prognosis, offering clinical guidance.

Area of Science:

  • Oncology
  • Pulmonology
  • Pathology

Background:

  • Pulmonary mucinous adenocarcinoma (PMA) is a distinct subtype of non-small cell lung cancer (NSCLC).
  • PMA is characterized by abundant mucin-producing cells and possesses unique clinical, pathological, and molecular characteristics.
  • Despite comprising a small fraction of lung adenocarcinomas, PMA warrants specific attention due to its distinct features.

Purpose of the Study:

  • To provide a comprehensive review of pulmonary mucinous adenocarcinoma (PMA).
  • To discuss the pathophysiology, etiology, clinical features, diagnostic methods, treatment strategies, and prognosis of PMA.
  • To serve as a reference for clinical practice in diagnosing, treating, and assessing PMA prognosis.

Main Methods:

  • Literature review of relevant studies and existing research on PMA.
  • Comprehensive analysis of pathophysiology, clinical presentation, diagnostics, and therapeutic approaches.
  • Examination of factors influencing prognosis, including molecular markers and pathological features.

Main Results:

  • PMA exhibits unique clinical, pathological, and molecular features compared to other NSCLC subtypes.
  • Treatment advances include surgical intervention, targeted therapy, immunotherapy, and adjuvant therapy.
  • Prognosis is influenced by molecular markers, pathological characteristics, and treatment efficacy.

Conclusions:

  • Pulmonary mucinous adenocarcinoma (PMA) requires specialized diagnostic and treatment approaches.
  • Understanding prognostic factors is crucial for effective patient management.
  • This review offers valuable guidance for clinicians managing PMA.
Keywords:
KRAS mutationsNSCLCPrognosticPulmonary mucinous adenocarcinomaTargeted therapy

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