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Updated: Jun 27, 2025
06:53
Cell Population Analyses During Skin Carcinogenesis
Published on: August 21, 2013
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Super giant basal cell carcinoma: a comprehensive systematic review
Ajaipal S Kang1, Genelia Kang2, Harjaap S Kathuria3
1Department of Surgery, UPMC Hamot.
Annals of Medicine and Surgery (2012)
|May 2, 2024
Summary
Super giant basal cell carcinoma (SGBCC) is a rare, aggressive skin cancer. This review found SGBCC commonly affects older males, often on the trunk, and may be linked to self-neglect and metastasis.
Area of Science:
- Dermatology
- Oncology
- Medical Research
Background:
- Super giant basal cell carcinoma (SGBCC), defined as >20 cm, is a rare and understudied oncological entity.
- Existing literature on SGBCC is scarce, necessitating a comprehensive review to understand its characteristics.
Purpose of the Study:
- To characterize SGBCC by analyzing patient demographics, risk factors, anatomical location, metastasis, and treatment modalities.
- To identify patterns and potential etiological factors contributing to the development of SGBCC.
Main Methods:
- A systematic literature search was conducted from 1972 to 2023, filtering for human, skin, English language, and SGBCC cases.
- Analysis of 20 identified case reports to extract data on age, sex, location, duration, metastasis, and treatment.
Main Results:
- SGBCC predominantly affects males (2:1 ratio) around age 61, with most lesions located on the trunk and present for over 10 years.
- Risk factors identified include low socioeconomic status and poor mental health; metastasis was reported in 7 of 20 cases.
- Treatment involved surgery (11 cases), radiation (6 cases), and immunotherapy (Vismodegib, 4 cases).
Conclusions:
- SGBCC is an aggressive form of basal cell carcinoma with a propensity for metastasis, contrasting with typical BCC prognosis.
- The findings suggest self-neglect may be an etiological factor in SGBCC development.
- Multimodal treatment approaches combining surgery, radiation, and immunotherapy are indicated for SGBCC.
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