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4D bioprinting of programmed dynamic tissues.

Jiahui Lai1,2, Yuwei Liu1,3, Gang Lu2,4

  • 1Department of Biomedical Engineering, The Chinese University of Hong Kong, NT, Hong Kong SAR, China.

Bioactive Materials
|May 2, 2024
PubMed
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4D bioprinting uses smart biomaterials to create dynamic living tissues that change over time. This advanced biofabrication technology holds significant potential for regenerative medicine and drug development.

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Materials Science

Background:

  • 4D printing enables the creation of dynamic structures that respond to stimuli over time.
  • 4D bioprinting integrates smart biomaterials and living cells for advanced biofabrication.
  • This technology is crucial for developing dynamic, programmed cell-laden constructs.

Purpose of the Study:

  • To provide a comprehensive overview of 4D bioprinting for engineering dynamic tissues and organs.
  • To discuss current approaches, technologies, materials, and applications in 4D bioprinting.
  • To highlight challenges and future perspectives in this rapidly evolving field.

Main Methods:

  • Review of existing literature on 4D bioprinting techniques and applications.
Keywords:
4D bioprintingBioprinting technologyProgrammed dynamic tissueSmart designSmart material

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  • Discussion of smart biomaterials, bioink requirements, and design strategies.
  • Analysis of challenges and future directions in transdisciplinary research.
  • Main Results:

    • 4D bioprinting is successfully applied in creating dynamic constructs for bone, cartilage, and vasculature.
    • Significant progress has been made in developing smart biomaterials and bioinks for 4D bioprinting.
    • The review outlines various approaches and technologies enabling 4D bioprinting.

    Conclusions:

    • 4D bioprinting offers immense potential for creating advanced dynamic tissues and organs.
    • Addressing current challenges requires transdisciplinary collaboration to unlock the full capabilities of this technology.
    • Future applications are expected in basic research, pharmaceutics, and regenerative medicine.