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Finding a Link between Obesity and Senescence: A Systematic Review and Meta-Analysis
Sry Suryani Widjaja1, Rusdiana Rusdiana1, Tengku Mardani Helvi1
1Department of Biochemistry, Medical Faculty, Universitas Sumatera Utara, Medan, Sumatera Utara, Indonesia.
Iranian Journal of Public Health
|May 2, 2024
Summary
Obesity accelerates cellular aging (senescence) by increasing inflammation and is linked to higher risks of multimorbidity. This systematic review confirms a reciprocal relationship between obesity and aging processes.
Area of Science:
- Gerontology
- Metabolic Health
- Inflammation Biology
Background:
- Cellular aging (senescence) is linked to telomere attrition and DNA damage, exacerbated by chronic inflammation in obesity.
- Obesity is a significant public health concern, particularly in aging populations.
Purpose of the Study:
- To systematically review and meta-analyze the relationship between obesity and aging or senescence.
- To elucidate the bidirectional interplay between obesity and the aging process.
Main Methods:
- Systematic review and meta-analysis adhering to PRISMA guidelines.
- Literature search across major databases (PubMed, Scopus, etc.) from 2012-2022.
- Risk of bias assessment using SYRCLE and Newcastle-Ottawa Scale, followed by quantitative analysis.
Main Results:
- Fifteen studies were included, revealing obesity and white adipose tissue increase pro-inflammatory and pro-senescence cytokines.
- Obesity affects 22% of the elderly population, with higher prevalence in women.
- Obesity significantly increases the risk of multimorbidity by 56% (OR = 1.58).
Conclusions:
- Obesity and aging exhibit a reciprocal relationship.
- Obesity contributes to cellular senescence and inflammation, while aging impairs metabolism and increases obesity risk.
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