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  11. Increased Long-term Risk Of Dementia In Patients With Carbon Monoxide Poisoning: A Systematic Review And Meta-analysis Of Cohort Studies

Increased Long-Term Risk of Dementia in Patients With Carbon Monoxide Poisoning: A Systematic Review and Meta-Analysis of Cohort Studies

Meixian Zhang1, Zhu Liduzi Jiesisibieke1, Ho-Shan Wei2

  • 1Enze Medical Research Center, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai, China.

Psychiatry Investigation
|May 2, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Carbon monoxide (CO) poisoning significantly elevates dementia risk. This finding highlights a critical link between CO exposure and cognitive decline, particularly in males and younger individuals.

Area of Science:

  • Neurology
  • Environmental Health
  • Epidemiology

Background:

  • Dementia represents a growing global health concern.
  • The potential impact of environmental toxins, such as carbon monoxide (CO), on dementia incidence requires thorough investigation.

Purpose of the Study:

  • To systematically evaluate the association between carbon monoxide (CO) poisoning and the risk of developing dementia.

Main Methods:

  • A systematic review and meta-analysis were conducted using data from the Cochrane Library, PubMed, and EMBASE up to August 14, 2022.
  • Inclusion criteria specified prospective cohort studies with adequate follow-up periods.
  • Study selection, quality assessment, and data extraction were performed independently by two authors, with disagreements resolved by a third.
Keywords:
Carbon monoxide poisoningCohort studyDementiaMeta-analysis

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Main Results:

  • Three cohort studies involving 134,563 participants initially free of dementia were included, with follow-up periods of 9-12 years.
  • Carbon monoxide (CO) poisoning was associated with a significantly increased risk of dementia incidence (adjusted hazard ratio 2.61; 95% CI 1.56-4.36).
  • Subgroup analyses revealed a higher dementia risk in males compared to females, and in younger and middle-aged groups compared to older adults.

Conclusions:

  • Prospective cohort studies provide evidence supporting a link between carbon monoxide (CO) exposure and an elevated risk of dementia.
  • The observed association warrants further research, particularly given that all included studies were from the Taiwanese population.