Analgesic Effectiveness of Dinalbuphine Sebacate in Video-Assisted Thoracoscopic Wedge Resection and Its Effect on Reducing Postoperative Pulmonary Complications: A Retrospective Cohort Study
View abstract on PubMed
Summary
This summary is machine-generated.A single preoperative injection of dinalbuphine sebacate (DS) effectively relieved pain in patients undergoing video-assisted thoracoscopic wedge resection. This approach reduced analgesic needs and oxygen therapy without increasing postoperative pulmonary complications.
Area Of Science
- Anesthesiology
- Thoracic Surgery
- Pain Management
Background
- Inadequate pain relief post-surgery can lead to complications like pulmonary issues.
- Video-assisted thoracoscopic wedge resection is a common thoracic surgical procedure.
Purpose Of The Study
- To evaluate the effectiveness of a single preoperative dinalbuphine sebacate (DS) injection for pain management.
- To determine if DS reduces postoperative pulmonary complications (PPCs) after thoracoscopic surgery.
Main Methods
- Retrospective review of 757 patients undergoing VATS wedge resection.
- Comparison between a dinalbuphine sebacate (DS) group and a conventional analgesia (CA) group.
- Analysis of analgesic consumption, PPC incidence, and oxygen therapy use.
Main Results
- The DS group showed reduced consumption of several analgesics but higher morphine and ketorolac use.
- Fewer patients in the DS group requested pain relief.
- No significant difference in PPC incidence, but DS group had less need for oxygen therapy, earlier chest tube removal, and shorter hospital stays.
Conclusions
- Preoperative DS injection provides effective pain relief and reduces the need for additional analgesics post-surgery.
- DS did not increase the incidence of PPCs.
- DS may improve patient prognosis by reducing oxygen therapy requirements and facilitating recovery.
Related Concept Videos
Depolarizing blockers are administered through intravenous injection. Succinylcholine is the most common choice of depolarizing blockers in emergency clinical practices. Although they have a rapid onset, they readily diffuse away from the motor end plate into the extracellular fluid. They are metabolized by enzymes such as liver butyrylcholinesterase and plasma pseudocholinesterases. This produces a short duration of action, typically 5-10 minutes long, unlike nondepolarizing blockers, which...
Thoracentesis(Thoracocentesis), commonly known as pleural tap, is a medical procedure where a 22 gauge needle is inserted into the pleural space, the area between the lung and chest wall. This procedure is commonly performed to diagnose or treat various respiratory disorders.
Description
Excess pleural fluid or air may accumulate in some respiratory disorders in the thoracic cavity. To treat pleural effusion, a physician conducts thoracentesis by carefully piercing the chest wall and entering...
Sigmoidoscopy and laparoscopy are distinct medical procedures that enable physicians to internally inspect different parts of the GI tract. Although they serve different purposes, each is essential for diagnosing and, in some cases, treating various medical conditions.
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
Endoscopy is a non-surgical medical technique used to examine a person's internal organs and vessels. This lesson will focus on two types of endoscopic studies: bronchoscopy and thoracoscopy.
Bronchoscopy
Description
Bronchoscopy is a procedure that involves direct visualization of the larynx, trachea, and bronchi for diagnostic and therapeutic purposes. A flexible fiber optic or rigid bronchoscope is used to carry out the procedure. The fiber-optic bronchoscope is more frequently used due...
Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx...
Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...

