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Related Concept Videos

Mechanism of Ciliary Motion01:05

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The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible for cell movement, while in higher organisms, these appendages help in the movement of the extracellular fluids within the body cavities.
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Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
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The primary cilium, made up of microtubules, acts as antennae on the cell surfaces for relaying external stimuli into the cells. These fine hair-like structures are present, generally one per cell. These are non-motile cilia in a 9+0 microtubules arrangement, where the central pair of microtubules are absent. The primary cilia arise from the basal body embedded in the cell membrane. Intraflagellar transport (IFT) carries requisite proteins from the cytoplasm to the cilium because the primary...
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Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
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Disorders of the Skeletal Muscle01:28

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The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
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Related Experiment Video

Updated: Jun 27, 2025

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Alexithymia in primary ciliary dyskinesia.

Hanife Tuğçe Çağlar1, Sevgi Pekcan1, Semih Erden2

  • 1Department of Pediatric Pulmonology, School of Medicine, Necmettin Erbakan University, Konya, Turkey.

Pediatric Pulmonology
|May 2, 2024
PubMed
Summary

Children with primary ciliary dyskinesia (PCD) show higher rates of alexithymia, a difficulty in identifying and describing emotions. This suggests a need for emotional support and evaluation in managing PCD.

Keywords:
Pediatric Quality of LifeToronto Alexithymia Scalealexithymiabronchiectasischronic respiratory disease

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Area of Science:

  • Pediatric Pulmonology
  • Psychosomatic Medicine
  • Clinical Psychology

Background:

  • Alexithymia, characterized by emotional processing deficits, is increasingly linked to physical health conditions.
  • Primary ciliary dyskinesia (PCD) significantly impacts children's emotional well-being due to disease uncertainty and management challenges.

Purpose of the Study:

  • To determine the prevalence of alexithymia in children diagnosed with PCD.
  • To investigate the relationship between alexithymia and the clinical management of childhood PCD.

Main Methods:

  • A cohort of children aged 8-18 with PCD and healthy controls were recruited.
  • Participants completed sociodemographic questionnaires and self-report scales, including the Toronto Alexithymia Scale (TAS-20).
  • Data were analyzed to compare alexithymia scores between groups and correlate them with clinical and quality of life measures.

Main Results:

  • Adolescents with PCD (age >14) exhibited significantly higher TAS-20 scores than controls (p=.007).
  • Alexithymia scores correlated negatively with pulmonary function tests and positively with disease severity markers like bronchiectasis and nasal polyps.
  • A significant correlation was found between TAS-20 scores and the child's reported Pediatric Quality of Life (PedsQL) score.

Conclusions:

  • Children with PCD demonstrate a higher likelihood of alexithymia compared to healthy peers.
  • Routine screening for alexithymia in pediatric PCD patients is recommended.
  • Pediatric pulmonologists should be aware of alexithymic traits in PCD and consider psychiatric referrals for non-compliant patients.