Janus Nanofibrous Patch with In Situ Grown Superlubricated Skin for Soft Tissue Repair with Inhibited Postoperative Adhesion

Qiusheng Wang ¹, Jingtao Du ¹, Jinmei Meng ¹

⁰Innovation Center for Textile Science and Technology, College of Textiles, Donghua University, Shanghai 201620, China.

Acs Nano +

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May 2, 2024

View abstract on PubMed

Summary

This study introduces a Janus nanofibrous patch (J-NFP) that prevents tissue adhesion and promotes healing. The J-NFP offers superlubricity and reactive oxygen species (ROS) scavenging for enhanced soft tissue repair.

Area Of Science

Biomaterials Science
Regenerative Medicine
Nanotechnology

Background

Postoperative adhesion is a significant complication in soft tissue repair.
Existing anti-adhesion patches often lack pro-healing properties and can lose their topography.
There is a need for advanced materials that combine anti-adhesion with tissue regenerative capabilities.

Purpose Of The Study

To develop a Janus nanofibrous patch (J-NFP) with both superlubricated anti-adhesion and reactive oxygen species (ROS) scavenging functions.
To evaluate the J-NFP's efficacy in preventing tissue adhesion and promoting soft tissue healing.
To overcome the limitations of existing patches regarding topography preservation and pro-healing capacity.

Main Methods

Sequential electrospinning to create a Janus structure with initiators and cerium oxide nanoparticles (CeNPs) on different sides.
Subsurface-initiated atom transfer radical polymerization to graft zwitterionic polymer brushes (poly(sulfobetaine methacrylate)) for superlubricity.
In vitro and in vivo assessments of anti-adhesion, ROS scavenging, anti-inflammatory effects, and tissue repair efficacy.

Main Results

The J-NFP exhibited a superlubricated surface with a 77% reduction in the coefficient of friction, preserving fibrous topography.
Significant reduction in protein, platelet, bacteria, and cell adhesion was observed.
The patch demonstrated effective ROS scavenging, modulated cytokine secretion, inhibited tissue adhesion, and promoted skin and intrauterine wound healing in rats.

Conclusions

The developed Janus nanofibrous patch (J-NFP) effectively prevents postoperative adhesion and promotes soft tissue repair.
The J-NFP's dual functionality of superlubricity and ROS scavenging offers a promising strategy for advanced wound healing applications.
This versatile strategy provides a new avenue for designing next-generation biomaterials for regenerative medicine.

Keywords:

Janus nanofibrous patch ROS scavenging antiadhesion in situ growth zwitterionic polymer brushes