Related Experiment Video
Updated: Jun 27, 2025
Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines
Published on: April 21, 2022
[Benign mesothelial tumors]
1Institut für Pathologie, Ruhr-Universität Bochum an den Universitätskliniken Bergmannsheil, Bürkle-de-la-Camp Platz 1, 44789, Bochum, Deutschland. iris.tischoff@rub.de.
Abstract:
Benign mesothelial tumors are rarer than malignant mesotheliomas and are often found in the peritoneum as incidental findings in women. They include the adenomatoid tumor (AT), the well-differentiated mesothelial tumor (WDPMT), the mesothelioma in situ (MIS), and the solid papillary mesothelial tumor (SPMT). ATs are always benign and predominantly manifest in the genital tract. WDPMTs can develop multifocally and are prone to recurrence, particularly in the case of incomplete resection. Only MISs are considered a confirmed precursor lesion of malignant mesothelioma according to the currently valid World Health Organization (WHO) classifications. As with malignant mesothelioma, alterations of BAP1, MTAP, and p16 are detectable for MIS in contrast to the other three tumors. SPMTs cannot be clearly assigned to the other mesothelial tumors and have so far only been described in the peritoneum in women with a benign course.
Insights
Benign mesothelial tumors, including adenomatoid tumors and well-differentiated mesothelial tumors, are rare. Mesothelioma in situ is the only confirmed precursor to malignant mesothelioma, showing specific genetic alterations.
Area of Science:
- Pathology
- Oncology
- Genetics
Context:
- Benign mesothelial tumors are less common than malignant mesotheliomas.
- These tumors are frequently discovered incidentally in the peritoneum, particularly in women.
- The main types include adenomatoid tumor (AT), well-differentiated mesothelial tumor (WDPMT), mesothelioma in situ (MIS), and solid papillary mesothelial tumor (SPMT).
Purpose:
- To differentiate benign mesothelial tumors from malignant counterparts.
- To clarify the precursor status of mesothelioma in situ (MIS) in relation to malignant mesothelioma.
- To highlight the distinct characteristics and clinical behavior of various benign mesothelial tumors.
Summary:
- Benign mesothelial tumors are rare, with ATs typically found in the genital tract and WDPMTs potentially recurring after incomplete resection.
- Mesothelioma in situ (MIS) is the sole precursor to malignant mesothelioma, sharing BAP1, MTAP, and p16 alterations.
- Solid papillary mesothelial tumors (SPMTs) present uniquely in the peritoneum of women with a benign outcome.
Impact:
- Provides a clearer classification of benign mesothelial tumors.
- Identifies MIS as a critical lesion for understanding malignant mesothelioma development.
- Aids in accurate diagnosis and management of mesothelial neoplasms.
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