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Updated: Jun 27, 2025

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

3.0K

[Cognitive impairment in patients with arterial hypertension]

V V Zakharov1, P A Chernousov1, K A Vekhova1

  • 1Sechenov First Moscow Medical University (Sechenov University), Moscow, Russia.

Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|May 2, 2024
PubMed

Insights

Arterial hypertension (AH) is a major risk factor for stroke and vascular cognitive impairment (VCI). Early detection via neuropsychological assessment and neuroimaging, coupled with antihypertensive and neuroprotective treatments like ethylmethylhydroxypyridine succinate (mexidol), is crucial for managing brain damage.

Area of Science:

  • Cardiology
  • Neurology
  • Pharmacology

Context:

  • Arterial hypertension (AH) is a primary risk factor for cardiovascular diseases.
  • Cerebrovascular complications, including stroke and vascular cognitive impairment (VCI), are significant consequences of sustained hypertension.
  • VCI serves as a clinical indicator of hypertensive brain damage.

Purpose:

  • To outline the diagnostic and management strategies for VCI in patients with AH.
  • To highlight the role of neuropsychological assessment and neuroimaging in identifying and confirming VCI.
  • To emphasize the importance of integrated patient management including antihypertensive and neuroprotective therapies.

Summary:

  • Patients with hypertension require neuropsychological assessment to detect and evaluate VCI severity.
  • Neuroimaging techniques are essential for confirming the vascular etiology of cognitive deficits.
  • Effective management necessitates antihypertensive therapy combined with neuroprotection.
  • Ethylmethylhydroxypyridine succinate (mexidol) demonstrates significant clinical efficacy as a neuroprotective agent.

Impact:

  • Improved identification and management of VCI in hypertensive patients.
  • Potential reduction in the progression of hypertensive brain damage and associated cognitive decline.
  • Clinical validation of ethylmethylhydroxypyridine succinate (mexidol) in managing AH-related neurological complications.

Keywords:
arterial hypertensioncerebral vascular diseasecognitive impairmentethylmethylhydroxypyridine succinatemexidolneuroprotection

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