Serum klotho associated with thyroid hormone in adults: A population-based cross-sectional research
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View abstract on PubMed
Summary
This summary is machine-generated.Serum klotho levels show a nonlinear relationship with thyroid hormones like free triiodothyronine (fT3) and total triiodothyronine (tT3). This suggests klotho
Area Of Science
- Endocrinology
- Molecular Biology
- Biochemistry
Background
- Klotho protein is implicated in endocrine diseases and thyroid cancer.
- The relationship between serum klotho and thyroid hormones is not well understood.
Purpose Of The Study
- To investigate the correlation between serum klotho levels and thyroid hormones.
- To explore the nonlinear association between klotho and thyroid hormones.
Main Methods
- Utilized NHANES data from 2007-2012, including 4674 participants.
- Employed multiple linear regression and restricted cubic spline plots (RCS).
- Analyzed associations between serum klotho and thyroid hormone levels.
Main Results
- Serum klotho positively correlated with tT3, tT4, fT3, and tT3/fT3.
- Serum klotho negatively correlated with TSH, tT4/tT3, and fT4/fT3.
- An L-shaped nonlinear relationship was observed between ln(klotho) and fT3/tT3, with a cut-off point.
Conclusions
- A significant L-shaped nonlinear relationship exists between ln(klotho) and fT3/tT3.
- Klotho may play a role in the physiological regulation of thyroid function.
- Gender and iodine levels may modify the klotho-thyroid hormone relationship.
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