Related Experiment Video
Updated: Jun 27, 2025
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
Evolution of hormonal therapy for prostate cancer
David Homewood1, Ming Hei Fu2, Niranjan Sathianathen3
1BSci, MD, Urology Research Registrar, Department of Urology, Western Health, Melbourne, Vic; Department of Surgery, University of Melbourne,@Melbourne, Vic; Research Fellow, International@Medical Robotics Academy, Melbourne, Vic.
Background:
Prostate cancer (PCa) is the most common malignancy after skin cancer in men in Australia. Its management varies according to tumour stage. Due to the significant dependence on androgen receptor signalling, agents that interfere with this pathway (most commonly medical castration in the form of androgen deprivation therapy [ADT]) are the mainstay treatment of advanced disease.
Objective:
This review provides a contemporary update on ADT, with further discussion of emerging novel therapies for primary care.
Discussion:
ADT is currently indicated for the treatment of metastatic prostate cancer, disease recurrence following attempted local curative therapy, as well as combined use with radiotherapy for intermediate/high-risk disease. There has been rapid development of new pharmaceuticals targeting the androgen receptor. These are reviewed historically with an emphasis placed on emerging therapies, their common side effects, and how to manage them in the general practice setting.
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