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Published on: February 26, 2013
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Long-term hyperuricemia impact on atrial fibrillation outcomes
Aurelio Quesada1, Javier Quesada-Ocete2, Blanca Quesada-Ocete3
1Arrhythmia Unit, Cardiology Service, General University Hospital Consortium of Valencia, Valencia, Spain; School of Medicine, Catholic University of Valencia San Vicente Mártir, Valencia, Spain; Department of Internal Medicine, Hospital Universitario y Politécnico La Fe, Valencia, Spain.
Current Problems in Cardiology
|May 2, 2024
Summary
High uric acid levels (hyperuricemia) are linked to worse outcomes in atrial fibrillation (AF) patients. This study found hyperuricemia independently increases mortality and heart failure risk in AF.
Area of Science:
- Cardiology
- Nephrology
- Internal Medicine
Background:
- Limited research exists on the impact of serum uric acid (UA) on atrial fibrillation (AF) patient prognosis.
- Hyperuricemia (HU) is a condition of elevated UA levels.
- This study investigates the prognostic value of HU in AF patients.
Purpose of the Study:
- To evaluate the effect of hyperuricemia on the prognosis of patients with atrial fibrillation.
- To determine if elevated serum uric acid levels are associated with adverse outcomes in AF.
Main Methods:
- A cohort of 1772 patients with atrial fibrillation (AF) was analyzed.
- Patients were categorized into groups based on serum uric acid (UA) levels (quartiles).
- Hyperuricemia (HU) was defined as UA levels in the highest quartile (≥7 mg/dL).
Main Results:
- Patients with HU (highest UA quartile) exhibited significantly higher all-cause mortality (52.1%) compared to those without HU (35.3%).
- Multivariate Cox analysis identified HU as an independent risk factor for death (HR 1.89).
- Kaplan-Meier survival analysis revealed shorter survival times in patients with HU (p<0.001) and increased risk of heart failure hospitalization.
Conclusions:
- Hyperuricemia is independently associated with increased all-cause mortality in atrial fibrillation patients.
- Elevated serum uric acid levels predict a higher risk of hospitalization for heart failure in AF patients.
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