Elevated serum homocysteine levels associated with poor recurrence-free and overall survival in patients with colorectal cancer
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.Elevated homocysteine (HCY) levels predict poor survival in colorectal cancer (CRC) patients. Higher HCY indicates increased mortality risk and can be used with other markers for better prognosis prediction.
Area Of Science
- Oncology
- Clinical Biochemistry
Background
- Colorectal cancer (CRC) poses a significant global health challenge.
- Identifying reliable prognostic markers for CRC patients is crucial for improving outcomes.
Purpose Of The Study
- To investigate the prognostic value of serum homocysteine (HCY) levels in predicting recurrence-free survival (RFS) and overall survival (OS) in CRC.
- To evaluate the potential of HCY as a supplementary marker alongside existing prognostic tools.
Main Methods
- Retrospective analysis of 1272 colorectal cancer patients.
- Statistical analysis including multivariate analysis and subgroup analysis.
- Development and validation of HCY-based prognostic nomograms.
Main Results
- Elevated HCY levels (cutoff 15.2 μmol/L) were significantly associated with poorer RFS and OS.
- High HCY was linked to older age, male gender, larger tumors, elevated CEA, and increased healthcare costs.
- Multivariate analysis indicated a 55.7% increased risk of adverse RFS and 61.4% increased risk of adverse OS with HCY > 15.2 μmol/L.
- HCY levels demonstrated value in supplementing CEA and pathological staging.
Conclusions
- Elevated serum HCY is a strong independent predictor of poor RFS and OS in CRC patients.
- HCY-based prognostic models offer improved discrimination and calibration compared to traditional staging systems.
- HCY holds potential as a valuable biomarker for comprehensive CRC prognosis assessment.
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
Related Concept Videos
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...