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  11. The Development Of Fatigue After Treatment For Pediatric Brain Tumors Does Not Differ Between Tumor Locations

The development of fatigue after treatment for pediatric brain tumors does not differ between tumor locations

Elin Irestorm1,2, Antoinette Y N Schouten-van Meeteren2, Marloes van Gorp2

  • 1Faculty of Medicine, Department of Paediatrics, Lund University, Lund, Sweden.

Pediatric Blood & Cancer
|May 2, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Childhood brain tumor survivors experience significant fatigue, influenced by treatment and sociodemographic factors rather than tumor location. Vulnerable patients may need targeted support years after treatment ends.

Area of Science:

  • Pediatric Oncology
  • Neuro-Oncology
  • Cancer Survivorship

Background:

  • Children and adolescents with brain tumors report higher fatigue levels compared to other childhood cancer survivors.
  • Tumor location is a potential factor influencing fatigue development in pediatric brain tumor patients.

Purpose of the Study:

  • To investigate the longitudinal development of fatigue in pediatric brain tumor survivors.
  • To identify risk factors for fatigue based on tumor location.

Main Methods:

  • Longitudinal assessment of fatigue using the PedsQL Multidimensional Fatigue Scale in 425 pediatric brain tumor patients.
  • Analysis of 1235 fatigue assessments over 8 years post-treatment using mixed models.
  • Stratification of fatigue development and risk factors by tumor location: infratentorial, supratentorial hemispheric, and supratentorial midline.
Keywords:
brain tumorsfatiguelongitudinaltumor location

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Main Results:

  • Cognitive fatigue increased over time; sleep-rest and general fatigue showed a biphasic pattern.
  • No significant differences in overall fatigue levels were observed between tumor locations.
  • Radiotherapy (infratentorial), centralization of care (supratentorial midline), and female sex (supratentorial hemispheric) were associated with increased fatigue in specific tumor groups.
  • Higher parental education correlated with reduced fatigue across all tumor locations.

Conclusions:

  • Fatigue development in pediatric brain tumor survivors is primarily linked to sociodemographic and treatment variables, not tumor location.
  • Healthcare providers should monitor for persistent fatigue years post-treatment.
  • Patients from lower/middle educational backgrounds may require targeted interventions and support.