Global research trends in CAR-T cell therapy for solid tumors: A comprehensive visualization and bibliometric study...

Area of Science:

• Oncology
• Immunotherapy
• Biotechnology

Background:

• CAR-T cell therapy is a significant approach for hematological malignancies.
• Its application in solid tumors is a rapidly growing area of research and clinical investigation.

Purpose of the Study:

• To conduct a bibliometric and knowledge map analysis of CAR-T cell therapy for solid tumors.
• To identify research trends, leading institutions, key authors, and emerging themes in this field.

Main Methods:

• Bibliometric analysis of publications retrieved from the Web of Science Core Collection (WoSCC).
• Knowledge map analysis to visualize research landscapes and collaborations.

Main Results:

• The field is experiencing rapid advancement, indicated by an increasing publication rate.
• The United States is the leading country, with the University of Pennsylvania as the most active institution.
• Carl H. June and Shannon L. Maude are identified as highly cited and co-cited authors, respectively; five main research hotspots and 10 emerging themes were identified.

Conclusions:

• CAR-T cell therapy for solid tumors is a dynamic and expanding research domain.
• Bibliometric analysis provides a comprehensive overview of the field's current status and future directions.
• Findings offer valuable insights for future research and development in CAR-T cell treatments for solid tumors.