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Updated: Jun 27, 2025

Author Spotlight: Biological Standardization to Ensure Reproducibility and Harmonization in Research
Published on: August 4, 2023
Publishing important work that lacks validity or reproducibility - pushing frontiers or corrupting science?
1Department of Biochemistry, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore, Republic of Singapore.
Abstract:
Scientific research requires objectivity, impartiality and stringency. However, scholarly literature is littered with preliminary and explorative findings that lack reproducibility or validity. Some low-quality papers with perceived high impact have become publicly notable. The collective effort of fellow researchers who follow these false leads down blind alleys and impasses is a waste of time and resources, and this is particularly damaging for early career researchers. Furthermore, the lay public might also be affected by socioeconomic repercussions associated with the findings. It is arguable that the nature of scientific research is such that its frontiers are moved and shaped by cycles of published claims inducing in turn rounds of validation by others. Using recent example cases of room-temperature superconducting materials research, I argue instead that publication of perceptibly important or spectacular claims that lack reproducibility or validity is epistemically and socially irresponsible. This is even more so if authors refuse to share research materials and raw data for verification by others. Such acts do not advance, but would instead corrupt science, and should be prohibited by consensual governing rules on material and data sharing within the research community, with malpractices appropriately sanctioned.
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