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Cushing's Syndrome in the Elderly.

Aleksandra Zdrojowy-Wełna1,2, Elena Valassi3,4

  • 1Department of Endocrinology, Diabetes and Isotope Therapy, Wroclaw Medical University, Wroclaw, Poland.

Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [And] German Diabetes Association
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Managing Cushing's syndrome (CS) in older adults is complex due to atypical symptoms and comorbidities. This review explores age-related differences in CS, focusing on diagnosis, treatment, and outcomes for the elderly.

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Area of Science:

  • Endocrinology
  • Geriatric Medicine

Background:

  • Cushing's syndrome (CS) presents unique management challenges in older patients.
  • Age-related physiological changes can affect diagnostic test interpretation.
  • Elderly individuals with CS experience higher mortality and impaired quality of life.

Purpose of the Study:

  • To review age-related differences in Cushing's syndrome etiology, clinical presentation, and outcomes.
  • To summarize current knowledge on therapeutic options for elderly CS patients.
  • To explore potential underlying mechanisms for age-related variations in CS.

Main Methods:

  • Comprehensive literature review of studies on Cushing's syndrome in different age groups.
  • Analysis of age-specific clinical features and diagnostic test performance.
  • Evaluation of treatment strategies and safety data in elderly populations.

Main Results:

  • Older patients often lack typical Cushing's syndrome features, complicating diagnosis.
  • Comorbidities are more prevalent in elderly CS patients, impacting management.
  • Limited data exists on the safety and efficacy of medical treatments in aged individuals.

Conclusions:

  • Effective therapeutic strategies for Cushing's syndrome in the elderly remain debated.
  • Further research is needed to establish optimal and safe treatment protocols for older CS patients.
  • Understanding age-related mechanisms is crucial for improving CS management in geriatrics.