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Related Experiment Video

Updated: Jun 27, 2025

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Durable immunomodulatory hierarchical patch for rotator cuff repairing.

Liren Wang1,2, Yonghang Liu3, Zhiqi Lin1,2

  • 1Department of Sports Medicine, Department of Orthopedics, Shanghai Institute of Microsurgery on Extremities, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 600 Yishan Road, Shanghai, 200233, China.

Bioactive Materials
|May 3, 2024
PubMed
Summary

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New rotator cuff tear patches using poly(ester-ferulic acid-urethane)urea (PEFUU) reduce inflammation and promote tissue regeneration. This approach improves healing at the tendon-to-bone interface, offering a promising solution for rotator cuff repair.

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Rotator cuff tears (RCTs) have high re-tear rates (>50%) with current degradable patches.
  • Degradable polymers alone fail to restore the inflammatory niche crucial for healing.
  • Existing treatments lack sustained anti-inflammatory properties.

Purpose of the Study:

  • To develop a novel degradable polymer patch with prolonged anti-inflammatory functionality for rotator cuff repair.
  • To create a hierarchical composite nanofiber patch (HCNP) mimicking natural tendon-to-bone interface microstructure.
  • To evaluate the efficacy of HCNP in promoting physiological healing and tissue regeneration in a rat RCT model.

Main Methods:

  • Synthesized poly(ester-ferulic acid-urethane)urea (PEFUU) by integrating ferulic acid (FA) into polyurethane.
Keywords:
Bioactive polymerBulk modificationFunctional regenerationInflammationTendon-to-bone interface

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  • Fabricated HCNP with aligned-random structure and incorporated decellularized Wharton jelly hydrolysate.
  • Assessed FA release, M1 macrophage modulation, stem cell differentiation, and in vivo healing in a rat RCT model.

    • Main Results:

    • PEFUU demonstrated sustained FA release, reversing M1 macrophage-induced inflammation.
    • HCNP successfully replicated tendon-to-bone microstructure and enhanced cartilage regeneration.
    • In vivo studies showed restored fiber alignment and tripartite collagen distribution (I-II-I) at the tendon-to-bone interface.
    • HCNP facilitated physiological healing and improved rotator cuff repair outcomes.

    Conclusions:

    • PEFUU-based HCNP offers a universal strategy for functionalizing degradable polymers.
    • The developed patch promotes effective musculoskeletal tissue regeneration by modulating the inflammatory niche.
    • This approach provides a foundational reference for future applications in tendon-to-bone healing and rotator cuff regeneration.