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Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

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Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
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Cerebellar volume measures may differentiate multiple sclerosis fallers from non-fallers.

Taylor N Takla1, Jennie Feldpausch1, Erin M Edwards1

  • 1Wayne State University.

Research Square
|May 3, 2024
PubMed
Summary

Cerebellar volumes in persons with multiple sclerosis (PwMS) correlate with motor and cognitive function. Specific cerebellar regions and their volumes distinguish fallers from non-fallers, suggesting imaging

Keywords:
Multiple sclerosiscerebellumcognitionfallsmotor functioning

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Area of Science:

  • Neuroimaging
  • Neuroscience
  • Radiology

Background:

  • The cerebellum, a common site for lesions in multiple sclerosis (MS), exhibits topographic organization with distinct motor and cognitive regions.
  • Understanding the relationship between cerebellar structure, function, and clinical outcomes in persons with MS (PwMS) is crucial for managing the disease.

Approach:

  • Applied a novel parcellation algorithm to MRI scans of 31 PwMS and 29 controls to divide the cerebellum into 28 regions.
  • Compared cerebellar volumes between PwMS and controls, and between MS fallers and non-fallers using Mann-Whitney U tests.
  • Assessed associations between cerebellar volumes and motor/cognitive function via Spearman correlations.

Key Points:

  • PwMS demonstrated poorer functional performance than controls.
  • Significant volumetric differences were observed in the corpus medullare, lobules I-III, and lobule V between PwMS and controls, largely driven by fallers.
  • Cerebellar volumes were significantly associated with both motor and cognitive task performance.

Conclusions:

  • Cerebellar lobule volumes critically influence motor and cognitive performance in PwMS.
  • Functional performance and cerebellar volumes effectively differentiate MS fallers from non-fallers.
  • Cerebellar imaging holds potential for predicting falls in PwMS.