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MIR-21 regulating distribution of intestinal flora through TNF-α promotes progression of ulcerative colitis
Yang Ke1, Xueni Liu2, Tao Niu3
1Gansu Provincial Maternity and Child-Care Hospital (Gansu Provincial Central Hospital), Department of Hematology and Oncology, Lanzhou, China.
Background:
To study the changes in intestinal flora in patients with ulcerative colitis (UC), and to explore its correlations with micro ribonucleic acid (miR)-21 and serum tumor necrosis factor-a (TNF-α).
Methods:
A total of 150 patients with UC were selected and divided into remission group and seizure group according to the severity of disease. At the same time, 150 healthy people receiving physical examination in the hospital during the same period were selected as control group. The levels of fecal miR-21 and TNF-α in all subjects were determined via reverse transcription-polymerase chain reaction (RT-PCR). The correlation between miR-21 and TNF-α and their associations with the changes in intestinal bacteria in UC were analyzed using Pearson correlation analysis. The risk factors affecting the occurrence of UC were explored via multivariate logistic regression analysis.
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