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Expression levels and diagnostic value of serum GDNF, CEA and CA199 in patients with colorectal carcinoma

  • 0The First Affiliated Hospital of Chongqing Medical University, Department of Gastroenterology, Chongqing, China.
Journal of Medical Biochemistry +

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May 3, 2024

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May 3, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Combined detection of glial cell line-derived neurotrophic factor (GDNF), carcinoembryonic antigen (CEA), and carbohydrate antigen 199 (CA199) significantly improves colorectal cancer (CRC) diagnosis. This approach offers high accuracy and reduces missed diagnoses in clinical settings.

Area Of Science

  • Oncology
  • Biochemistry
  • Medical Diagnostics

Background

  • Colorectal carcinoma (CRC) diagnosis relies on various biomarkers.
  • Glial cell line-derived neurotrophic factor (GDNF), carcinoembryonic antigen (CEA), and carbohydrate antigen 199 (CA199) are potential indicators for CRC.

Purpose Of The Study

  • To investigate the expression levels of GDNF, CEA, and CA199 in CRC patients.
  • To evaluate the diagnostic value of these biomarkers, individually and in combination, for CRC.

Main Methods

  • A study involving 150 participants: 50 CRC patients, 50 with benign colonic diseases, and 50 healthy controls.
  • Serum levels of GDNF, CEA, and CA199 were measured using a fully-automated electrochemiluminometer.
  • Receiver operating characteristic (ROC) curve analysis was performed to assess diagnostic accuracy.

Main Results

  • CRC patients exhibited significantly higher CEA and CA199 levels and lower GDNF levels compared to control groups (P<0.001).
  • Combined detection demonstrated high sensitivity (96.0%) and specificity (94.0%).
  • The area under the ROC curve (AUC) for combined detection was 0.950 (95% CI: 0.909-0.991), indicating excellent diagnostic performance.

Conclusions

  • Combined analysis of serum GDNF, CEA, and CA199 is a reliable method for improving CRC diagnostic accuracy.
  • This strategy effectively reduces the rate of missed diagnoses.
  • The combined biomarker approach holds significant clinical application value for CRC detection.

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