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Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells
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Clinical significance of immune-related antigen CD58 in gliomas and analysis of its potential core related gene
Zhi Tian1, Wei Jia2, Zhao Wang1
1Department of Neurosurgery, First Affiliated Hospital, Jishou University, Jishou, Hunan, 416000 PR China.
Heliyon
|May 3, 2024
Summary
High CD58 expression indicates a worse prognosis in glioma, correlating with increased malignancy and mortality. CD58 and its core genes may offer new biomarkers for glioma diagnosis and treatment.
Area of Science:
- Oncology
- Immunology
- Genetics
Background:
- The clinical significance of the immune-related antigen CD58 in gliomas is not well understood.
- Previous research has not definitively established the role of CD58 in glioma progression or its potential as a therapeutic target.
Purpose of the Study:
- To investigate the clinical importance of CD58 in gliomas.
- To identify core related genes associated with CD58 in glioma.
Main Methods:
- Pan-cancer analysis to assess CD58 association with various tumors.
- Glioma RNA sequencing and clinical sample analysis to examine CD58's relationship with glioma.
- shRNA interference models to evaluate CD58's impact on glioma cell function.
- Exploration of core related genes using four glioma datasets and two online platforms.
Main Results:
- High CD58 expression is linked to poorer prognosis across multiple tumors and increased glioma malignancy.
- Downregulation of CD58 reduced glioma cell proliferation, enhanced apoptosis, and decreased metastasis.
- Identified core genes (CASP1, CCL2, IL18, MYD88, PTPRC, TLR2) involved in CD58-related immune pathways.
- A CD58 and core gene signature demonstrated strong predictive power for glioma prognosis.
Conclusions:
- High CD58 expression correlates with more malignant glioma subtypes and is an independent risk factor for glioma mortality.
- CD58 and its core-related genes show potential as novel biomarkers for glioma diagnosis and treatment.
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