Impact of sarcopenia on variceal rebleeding in patients after endoscopic therapy: a multicenter retrospective cohort study based on propensity score matching
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View abstract on PubMed
Summary
This summary is machine-generated.Sarcopenia, a common complication in liver cirrhosis, significantly increases the risk of rebleeding after endoscopic therapy. Early nutritional assessment for sarcopenia is crucial for managing patients with liver cirrhosis.
Area Of Science
- Hepatology
- Gastroenterology
- Clinical Nutrition
Background
- Sarcopenia is a frequent complication in liver cirrhosis patients.
- It is associated with poor prognostic outcomes.
- Its role in post-endoscopic therapy outcomes requires further investigation.
Purpose Of The Study
- To evaluate the impact of sarcopenia on rebleeding and mortality in liver cirrhosis patients following endoscopic treatment.
- To determine if sarcopenia is an independent predictor of adverse outcomes after endoscopic therapy.
Main Methods
- Retrospective enrollment of liver cirrhosis patients who underwent endoscopic therapy.
- Application of Propensity Score Matching (PSM) to minimize selection bias.
- Recording of two-year rebleeding episodes and mortality rates post-endoscopic therapy.
Main Results
- Sarcopenia was present in 32.4% of the study cohort (109 patients).
- Sarcopenic patients exhibited significantly higher rebleeding rates both before (41.3% vs. 15.9%) and after PSM (44.4% vs. 15.3%).
- Multivariable analysis confirmed sarcopenia as an independent predictor of 2-year rebleeding (HR: 2.596 pre-PSM, HR: 3.490 post-PSM).
Conclusions
- Sarcopenia is significantly associated with an increased risk of rebleeding in liver cirrhosis patients after endoscopic treatment.
- Pre-treatment nutritional assessment, including evaluation for sarcopenia, is essential for risk stratification and management.
- Identifying sarcopenia can guide therapeutic strategies to improve outcomes in liver cirrhosis patients.
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