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Updated: Jun 27, 2025

Body Composition and Metabolic Caging Analysis in High Fat Fed Mice
Published on: May 24, 2018
Corticotropin-releasing hormone and obesity: From fetal life to adulthood
Inês Vasconcelos1, Madalena von Hafe1, Rui Adão1,2,3
1Cardiovascular R&D Centre-UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal.
Abstract:
Obesity is among the most common chronic disorders, worldwide. It is a complex disease that reflects the interactions between environmental influences, multiple genetic allelic variants, and behavioral factors. Recent developments have also shown that biological conditions in utero play an important role in the programming of energy homeostasis systems and might have an impact on obesity and metabolic disease risk. The corticotropin-releasing hormone (CRH) family of neuropeptides, as a central element of energy homeostasis, has been evaluated for its role in the pathophysiology of obesity. This review aims to summarize the relevance and effects of the CRH family of peptides in the pathophysiology of obesity spanning from fetal life to adulthood.
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