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Autoantibodies against complement proteins in patients with antiphospholipid syndrome: Prevalence and clinical
Rémi Philip1,2,3, Achille Aouba1,3, Nicolas Martin Silva1
1Department of Clinical Immunology and Internal Medicine, CHU of Caen Normandie, Caen, France.
Abstract:
Seventy-seven patients with antiphospholipid syndrome were tested for autoantibodies against C1q, C3, FB, FH, and C4bp. Fifty-seven patients had at least one anti-complement antibody. IgM anti-FH positivity was associated with thrombosis when anti-C3 and anti-FB were, negatively or positively, associated with various noncriteria manifestations of antiphospholipid syndrome.
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