A survey of multiple candidate probiotic bacteria reveals specificity in the ability to modify the effects of key wound pathogens
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View abstract on PubMed
Summary
This summary is machine-generated.Probiotic extracts show varied effects on wound pathogens. Some inhibit growth and biofilm formation, while others may stimulate pathogen growth, highlighting the need for careful strain selection for topical applications.
Area Of Science
- Microbiology
- Dermatology
- Probiotics Research
Background
- Probiotics are investigated for topical therapies against skin pathogens.
- The safety and efficacy of topical probiotic application, especially on compromised skin, require further investigation.
- Probiotic extracts may offer advantages over live bacteria for topical use.
Purpose Of The Study
- To evaluate the inhibitory effects of probiotic supernatants and lysates on wound pathogen growth and biofilm formation.
- To assess the ability of probiotic extracts to protect human keratinocytes from pathogen-induced toxicity.
- To determine the species-specific impact of different probiotic extracts on wound pathogens.
Main Methods
- Supernatants and sonicated lysates from five candidate probiotics (Lactiplantibacillus plantarum, Limosilactobacillus reuteri, Bifidobacterium longum, Lacticaseibacillus rhamnosus GG, Escherichia coli Nissle 1917) were tested.
- Inhibitory effects were assessed against wound pathogens: Staphylococcus aureus, Streptococcus pyogenes, Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumanni.
- Effects on pathogen growth, biofilm formation, and keratinocyte protection were evaluated.
Main Results
- Probiotic supernatants reduced the growth of S. aureus, E. coli, and A. baumanni; B. longum also inhibited P. aeruginosa.
- Probiotic lysates inhibited S. pyogenes (L. plantarum, L. reuteri) and E. coli/S. aureus (B. longum).
- Some probiotic extracts, particularly neutralized Lactobacillus supernatants and E. coli Nissle 1917 lysates, showed varied or stimulatory effects on pathogen growth and biofilm formation, with L. reuteri and E. coli Nissle protecting keratinocytes.
Conclusions
- Probiotic extracts, including lactobacilli and E. coli Nissle lysates, can inhibit pathogenic growth independently of acidification.
- Probiotic extracts can beneficially alter host cell-pathogen interactions in a species-specific manner.
- The study underscores the critical need for careful selection of probiotic species and strains for topical applications due to variable effects on pathogens.
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