Related Experiment Video

Updated: Jun 27, 2025

Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health
06:13

Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health

Published on: December 1, 2023

1.1K

Automated insulin delivery in children with type 1 diabetes during physical activity: a meta-analysis

Yuan-Yuan Wang1, Hui-Min Ying1, Fang Tian1

  • 1Department of Endocrinology, 631689 Xixi Hospital of Hangzhou , Hangzhou, Zhejiang Province, P.R. China.

Journal of Pediatric Endocrinology & Metabolism : JPEM
|May 3, 2024
PubMed

Insights

Automated insulin delivery (AID) systems improve time in range and reduce hyperglycemia in children with type 1 diabetes (T1D). However, AID did not significantly lower post-exercise hypoglycemia compared to other pump systems.

Area of Science:

  • Pediatric Endocrinology
  • Metabolic Disorders
  • Biomedical Engineering

Background:

  • Type 1 diabetes (T1D) management in pediatric populations presents unique challenges, especially during physical activity.
  • Automated insulin delivery (AID) systems offer a potential solution for optimizing glycemic control in adolescents and children with T1D.

Purpose of the Study:

  • To evaluate the efficacy of automated insulin delivery (AID) systems in adolescents and children with type 1 diabetes (T1D) during physical activity.
  • To compare the performance of AID with traditional insulin pump systems in managing T1D during exercise.

Main Methods:

  • A systematic literature search was conducted in Cochrane Library, PubMed, and Embase.
  • Keywords included "Child", "Insulin Infusion Systems", and "Diabetes Mellitus".
  • Twelve studies involving 514 patients were analyzed.

Main Results:

  • AID systems did not demonstrate a significant reduction in hypoglycemia duration during physical activity (p>0.99).
  • Time in range (TIR) was significantly higher with AID compared to non-AID pumps (p<0.001).
  • Hyperglycemic time was significantly decreased in the AID group (p<0.05).

Conclusions:

  • Automated insulin delivery (AID) improves TIR and reduces hyperglycemia in pediatric T1D patients.
  • AID did not show a significant benefit in reducing post-exercise hypoglycemia compared to open loop or sensor-augmented pumps.
  • Further research is warranted to confirm potential benefits of AID on hypoglycemia duration during physical activity.
Abstract

Keywords:
childinsulin infusion devicesphysical activitytype 1 diabetes

More Related Videos

Physical Activity Measurement in Children Accepting Table Tennis Training06:51

Physical Activity Measurement in Children Accepting Table Tennis Training

Published on: July 27, 2022

1.9K
Author Spotlight: Advancing Diabetes Research with Static Exercise Training in Mice03:17

Author Spotlight: Advancing Diabetes Research with Static Exercise Training in Mice

Published on: March 29, 2024

475

Related Concept Videos

Insulin: Dosing Regimen and Adverse Effects01:16

Insulin: Dosing Regimen and Adverse Effects

Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
168
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.6K
Insulin Formulations: Types and Delivery01:27

Insulin Formulations: Types and Delivery

Insulin preparations are categorized by their duration of action into short-acting and long-acting types. Two strategies are used to modify insulin's absorption and pharmacokinetic profile: slowing the absorption post-subcutaneous injection, or altering human insulin's amino acid sequence or protein structure. These changes retain the insulin's ability to bind to the insulin receptor, but alter its behavior in solution or after injection.
Short-acting insulins are divided into...
191
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.3K
Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
268