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Related Concept Videos

Interphase00:54

Interphase

175.0K
The cell cycle occurs over approximately 24 hours (in a typical human cell) and in two distinct stages: interphase, which includes three phases of the cell cycle (G1, S, and G2), and mitosis (M). During interphase, which takes up about 95 percent of the duration of the eukaryotic cell cycle, cells grow and replicate their DNA in preparation for mitosis.
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Cell Motility through Blebbing01:16

Cell Motility through Blebbing

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Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
Blebbing Through the Matrix
In multicellular...
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Distribution of Cytoplasmic Content02:33

Distribution of Cytoplasmic Content

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Cytokinesis segregates a cell’s chromosomes and organelles into its daughter cells. Organelles divide and grow prior to cell division but cannot be synthesized de novo; therefore, cells must receive at least one copy of each organelle to survive. Currently, many of the details of how the organelles are distributed are not yet fully elucidated.
Distribution of cytoplasmic determinants
The cytoplasm contains various organelles, as well as salts, proteins, and water. The distribution of...
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Protein Transport into the Inner Mitochondrial Membrane01:34

Protein Transport into the Inner Mitochondrial Membrane

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Nuclear encoded mitochondrial precursors are imported to the inner membrane in a multistep process involving two separate translocons, TIM22 and TIM23. TIM23 is a cation-selective pore that remains closed by the N terminal segment of the protein. Negative charges on the TIM23 act as a receptor for the incoming precursor, pulling the positively charged matrix-targeting sequence for peptide insertion and translocation.
Transport of mitochondrial precursors across the TIM23 channel is driven by...
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Condensins02:15

Condensins

3.5K
Condensins are large protein complexes that use ATP to fuel the assembly of chromosomes during mitosis. They transform the tangled, shapeless mass of post-interphase DNA into individualized chromosomes by compacting, organizing, and segregating chromosomal DNA.
The plant and animal cells contain two types of condensin complexes—condensin I and condensin II. Both complexes have five subunits: two SMC (Structural Maintenance of Chromosomes) subunits, a kleisin subunit, and two HEAT-repeat...
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Entropy within the Cell01:22

Entropy within the Cell

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A living cell's primary tasks of obtaining, transforming, and using energy to do work may seem simple. However, the second law of thermodynamics explains why these tasks are harder than they appear. None of the energy transfers in the universe are completely efficient. In every energy transfer, some amount of energy is lost in a form that is unusable. In most cases, this form is heat energy. Thermodynamically, heat energy is defined as the energy transferred from one system to another that...
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Related Experiment Video

Updated: Jun 27, 2025

The C. elegans Intestine As a Model for Intercellular Lumen Morphogenesis and In Vivo Polarized Membrane Biogenesis at the Single-cell Level: Labeling by Antibody Staining, RNAi Loss-of-function Analy
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The C. elegans Intestine As a Model for Intercellular Lumen Morphogenesis and In Vivo Polarized Membrane Biogenesis at the Single-cell Level: Labeling by Antibody Staining, RNAi Loss-of-function Analy

Published on: October 3, 2017

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The enigma of cell intercalation.

Raphaël Clément1

  • 1Institut de Biologie du Développement de Marseille, Aix Marseille University, CNRS, Marseille, France.

Elife
|May 3, 2024
PubMed
Summary

Geometric criteria distinguish active from passive cell intercalation during tissue convergent extension. This analysis aids in understanding tissue morphogenesis and cellular dynamics.

Area of Science:

  • Cell biology
  • Developmental biology
  • Tissue engineering

Background:

  • Convergent extension is a key morphogenetic process involving cell intercalation.
  • Distinguishing active vs. passive cell intercalation is crucial for understanding tissue development.

Discussion:

  • Geometric criteria offer a quantitative method to assess cell intercalation mechanisms.
  • This approach can differentiate between intrinsic cellular forces and extrinsic tissue tensions.

Key Insights:

  • Cell intercalation can be classified as active or passive based on geometric parameters.
  • This classification provides insights into the underlying cellular behaviors driving tissue shaping.

Outlook:

  • Further refinement of geometric criteria can improve predictive models of tissue morphogenesis.
Keywords:
D. melanogastercell intercalationconvergent extensiondevelopmentdevelopmental biologygeometryphysics of living systemstissue morphogenesis

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  • Applications include understanding developmental defects and guiding tissue regeneration strategies.