GelMA-based hydrogel biomaterial scaffold: A versatile platform for regenerative endodontics

Area of Science:

• Biomaterials Science
• Regenerative Medicine
• Endodontics

Background:

• Endodontic therapy is limited to mature teeth, necessitating regenerative strategies.
• Dental pulp regeneration faces challenges despite tissue engineering advancements.
• Gelatin methacryloyl (GelMA) hydrogels offer injectability, rapid gelation, and biocompatibility for scaffolds.

Purpose of the Study:

• To review the application of GelMA hydrogels as regenerative scaffolds in endodontics.
• To provide direction for future research in dental pulp regeneration.
• To discuss GelMA synthesis, characterization, and application in root canal therapy.

Main Methods:

• Literature review focusing on GelMA hydrogels in dental pulp regeneration.
• Analysis of GelMA's properties relevant to tissue engineering scaffolds.
• Discussion of current research and future directions in GelMA-based endodontic regeneration.

Main Results:

• GelMA hydrogels are effective scaffolds for delivering stem cells and growth factors.
• GelMA facilitates pulp tissue repair and regeneration.
• Existing research on GelMA in this field is scattered, highlighting the need for a comprehensive review.

Conclusions:

• GelMA hydrogels are pivotal biomaterials for dental pulp regeneration.
• Optimizing GelMA formulations and host tissue integration are key future challenges.
• This review provides insights and strategies for advancing GelMA-based endodontic regeneration.