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Related Concept Videos

Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

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The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
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Chronic Pancreatitis I: Introduction01:24

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The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
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Appendicitis-II: Diagnostic Studies and Management01:29

Appendicitis-II: Diagnostic Studies and Management

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Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
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  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Patterns, Timing And Predictors Of Recurrence Following Pancreaticoduodenectomy For Distal Cholangiocarcinoma: An International Multicentre Retrospective Cohort Study.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Patterns, Timing And Predictors Of Recurrence Following Pancreaticoduodenectomy For Distal Cholangiocarcinoma: An International Multicentre Retrospective Cohort Study.

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Modified Single-Loop Reconstruction for Pancreaticoduodenectomy
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Patterns, timing and predictors of recurrence following pancreaticoduodenectomy for distal cholangiocarcinoma: An international multicentre retrospective cohort study.

Peter Lz Labib1, Thomas B Russell1, Jemimah L Denson1

  • 1University Hospitals Plymouth NHS Trust, Plymouth, United Kingdom.

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
|May 3, 2024

View abstract on PubMed

Summary
This summary is machine-generated.
Keywords:
CholangiocarcinomaCohort studiesPancreatic neoplasmsPancreaticoduodenectomy

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Two-thirds of patients experience cancer recurrence after distal cholangiocarcinoma (dCCA) surgery, with most recurrences appearing within three years. Key recurrence predictors include histological features and disease stage.

Area of Science:

  • Oncology
  • Surgical Oncology
  • Gastroenterology

Background:

  • Pancreaticoduodenectomy for distal cholangiocarcinoma (dCCA) is frequently followed by cancer recurrence.
  • Understanding recurrence patterns and risk factors is crucial for optimizing surveillance and treatment strategies.

Purpose of the Study:

  • To determine the timing, patterns, and predictive factors of cancer recurrence after pancreaticoduodenectomy for dCCA.

Main Methods:

  • A multicentre retrospective cohort study included 198 patients with dCCA who underwent pancreaticoduodenectomy.
  • Five-year follow-up data were analyzed for recurrence patterns, survival, and associated factors using univariable and multivariable regression analyses.

Main Results:

  • 65% of patients recurred, with local-only (15%), distant-only (22%), and mixed patterns (28%) observed.
Recurrence
Survival
  • Recurrence most commonly occurred within three years post-surgery, with primary sites including the pancreatic bed, liver, and lung.
  • Multivariable analysis identified female sex, venous resection, advanced histological stage, and lymphatic invasion as predictors of recurrence.

    • Conclusions:

    • Cancer recurrence is common after pancreaticoduodenectomy for dCCA, affecting two-thirds of patients.
    • The majority of recurrences manifest within three years, predominantly in the pancreatic bed, liver, and lung.
    • Histological features significantly predict recurrence risk, informing potential therapeutic interventions.