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Updated: Jun 27, 2025

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries

Published on: March 31, 2021

Sesquilignans: Current research and potential prospective.

Ying Wu¹, Chao Ding¹, Zilong Zhang¹

¹School of Pharmacy, Shaanxi Key Laboratory of Research and Application of "Taibai Qi Yao", Shaanxi University of Chinese Medicine, Xianyang, 712046, PR China.

European Journal of Medicinal Chemistry

|May 3, 2024

Summary

This summary is machine-generated.

Sesquilignans, plant compounds with diverse structures, show promising pharmacological activities like antioxidant and antitumor effects. Chemical modifications, particularly methoxylation, can enhance these beneficial properties.

Keywords:

Bioactivity diversity Chemical diversity Constitutive relationship Sesquilignans

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Area of Science:

Natural Product Chemistry
Phytochemistry
Medicinal Chemistry

Background:

Lignans, prevalent in plant xylem and resins, are C6-C3 dimers.
Trimeric sesquilignans, a complex class of lignans, are increasingly studied.
Over 200 sesquileignan derivatives from ~50 plant families have been identified.

Purpose of the Study:

To review the chemical diversity of sesquilignans.
To summarize their known bioactivities.
To explore structure-activity relationships for enhanced development.

Main Methods:

Literature review of sesquileignan isolation and identification.
Analysis of reported pharmacological properties.
Correlation of chemical structures with bioactivity.

Main Results:

Sesquileignan structures vary, including monoepoxy, bisepoxy, and benzofuran types.
Pharmacological effects include antioxidant, hepatoprotective, antitumor, and anti-inflammatory activities.
Methoxylation enhances activity, while phenolic hydroxyl and glycosides reduce it.

Conclusions:

Sesquileignans exhibit significant chemical diversity and pharmacological potential.
Understanding structure-activity relationships is crucial for optimizing their therapeutic applications.
This review provides a foundation for further research and utilization of sesquileignans.