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Addressing challenges for repairing adult spinal cord with insights from neonates

Mickey E Abraham1, Joel Martin2, Joseph D Ciacci1

  • 1Department of Neurological Surgery, University of California, San Diego, La Jolla, CA 92037, USA.

Cell Stem Cell
|May 3, 2024
PubMed

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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