Related Experiment Video

Updated: Jun 27, 2025

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
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Androgen Deprivation Therapy/Androgen Receptor Signaling Inhibitor Treatments for Prostate Cancer: Pathophysiology

Richard Orji, Alicia Morgans1, Eiman Jahangir2

  • 1Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.

Southern Medical Journal
|May 3, 2024
PubMed

Insights

Androgen deprivation therapy for prostate cancer can cause cardiovascular issues due to testosterone suppression or medications. Regular heart screening is vital for patients on this treatment.

Area of Science:

  • Oncology
  • Cardiology
  • Pharmacology

Background:

  • Androgen deprivation therapy (ADT) is a primary treatment for advanced prostate cancer.
  • ADT induces hypogonadism and involves medications with potential side effects.
  • Cardiovascular complications are a significant concern associated with ADT.

Purpose of the Study:

  • To review the cardiovascular complications linked to ADT and androgen receptor signaling inhibitors (ARSIs).
  • To highlight the association between ADT/ARSIs and specific cardiovascular events.
  • To emphasize the importance of cardiovascular monitoring in prostate cancer patients receiving ADT.

Main Methods:

  • Systematic literature review.
  • Critical analysis of studies on ADT, ARSIs, and cardiovascular outcomes.
  • Synthesis of evidence regarding cardiovascular risks.

Main Results:

  • ADT and ARSIs are associated with prolonged QT interval, atrial fibrillation, and heart failure.
  • Increased risk of atherosclerosis, coronary heart disease, venous thromboembolism, and peripheral arterial occlusive disease.
  • Adverse cardiovascular effects stem from induced hypogonadism and treatment medications.

Conclusions:

  • ADT and ARSIs significantly increase cardiovascular risk in prostate cancer patients.
  • Proactive cardiovascular screening and management are essential during ADT.
  • Further research is needed to mitigate these cardiovascular risks.

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