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Statins in Chronic Liver Disease: Review of the Literature and Future Role

Nguyen Pham1, Jihane N Benhammou1,2,3

  • 1Department of Medicine, University of California, Los Angeles, Los Angeles, California.

Seminars in Liver Disease
|May 3, 2024
PubMed

Insights

Statins show promise in managing chronic liver disease (CLD) and preventing liver cancer. Their anti-inflammatory and immune-protective effects offer potential benefits beyond cholesterol reduction for liver health.

Area of Science:

  • Hepatology and Pharmacology
  • Translational Medicine

Background:

  • Chronic liver disease (CLD) presents a significant global health challenge with limited therapeutic advancements.
  • Statins, primarily used for cardiovascular disease, are increasingly recognized for their potential in liver disease management.

Purpose of the Study:

  • To review the clinical benefits of statins in various chronic liver disease (CLD) etiologies and hepatocellular carcinoma (HCC).
  • To explore the multifaceted mechanisms of action of statins relevant to liver health.
  • To discuss the potential role of statins in precision hepatology.

Main Methods:

  • Comprehensive literature review of studies investigating statin use in CLD and HCC.
  • Analysis of preclinical and clinical data on statin mechanisms in liver disease.
  • Exploration of emerging evidence on genetic influences on statin efficacy.

Main Results:

  • Statins exhibit anti-inflammatory, antiproliferative, and immune-protective effects beneficial for liver health.
  • Evidence suggests clinical benefits of statins across viral and nonviral CLD, and in HCC treatment.
  • The chemopreventive role of statins in CLD may offer the most substantial impact.

Conclusions:

  • Statins possess pleiotropic effects that extend their utility to CLD management and prevention.
  • Further research is warranted to elucidate the role of statins in precision hepatology, considering genetic variations.
  • Statins represent a promising therapeutic avenue for improving outcomes in patients with chronic liver disease.

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