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The role of lidocaine in cancer progression and patient survival
Kohei Chida1, Hirofumi Kanazawa2, Hirotaka Kinoshita3
1Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA; Department of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine, Hirosaki 036-8562, Japan.
Pharmacology & Therapeutics
|May 3, 2024
Summary
Lidocaine, a common local anesthetic, shows potential antitumor effects by impacting cancer cells and the tumor microenvironment. Further research is needed to clarify its mechanisms and clinical roles in cancer biology, especially during the perioperative period.
Area of Science:
- Oncology
- Anesthesiology
- Molecular Biology
Background:
- Lidocaine is a widely used local anesthetic agent since 1943.
- It functions by altering neuronal signal transmission via sodium channel blockade.
- Emerging evidence suggests lidocaine possesses potential antitumor properties, particularly in vitro.
Purpose of the Study:
- To review the mechanisms of lidocaine's local anesthetic action.
- To explore lidocaine's effects on cancer cells and the tumor microenvironment.
- To examine lidocaine's impact on cancer progression and clinical outcomes.
Main Methods:
- Literature review of existing studies on lidocaine.
- Analysis of in vitro and clinical data regarding lidocaine's antitumor effects.
- Investigation of pathways involved in lidocaine's action on cancer.
Main Results:
- Lidocaine's anesthetic mechanism involves prolonging sodium channel inactivation.
- Local administration of lidocaine perioperatively has improved survival in breast cancer patients.
- The precise mechanisms underlying lidocaine's antitumor effects are not fully understood.
Conclusions:
- Lidocaine exhibits potential anticancer effects, warranting further investigation.
- Understanding lidocaine's role in cancer biology, especially perioperatively, remains ambiguous.
- Further research is crucial to elucidate lidocaine's mechanisms and clinical applications in oncology.
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